Evidence map›Paper›PMID 41307476›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2026

Maternal Myo-Inositol Intake and Congenital Heart Defects in Offspring: A Population-Based Case-Control Study.

Ruiqi Cen, L Joseph Su, Jun Ying, Mohammed S Orloff, Elijah H Bolin, Xiangyang Lou, Lynn M Almli, Lorenzo D Botto, Marilyn L Browne, Richard H Finnell and 7 more

Abstract read
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In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ruiqi CenDepartment of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID https://orcid.org/0000-0002-2668-4901
L Joseph SuPeter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jun YingDepartment of Family Medicine, University of Colorado School of Medicine, Colorado, Aurora, USA.
Mohammed S OrloffDepartment of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Elijah H BolinArkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Xiangyang LouCollege of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.
Lynn M AlmliNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Lorenzo D BottoDepartment of Pediatrics, Division of Medical Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Marilyn L BrowneNew York State Department of Health, Birth Defects Registry, Albany, New York, USA.
Richard H FinnellBaylor College of Medicine, Center for Precision Environmental Health, Houston, Texas, USA.
Mary M JenkinsNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Eirini NestoridiDivision for Surveillance, Research, and Promotion of Perinatal Health, Massachusetts Department of Public Health, Boston, Massachusetts, USA.
Andrew F OlshanGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Paul A RomittiDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.
Gary M ShawDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Wendy N NembhardDepartment of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
National Birth Defects Prevention Study

Funding

CDC HHSNCBDD CDC HHS U01 DD001227NCBDD CDC HHS U01 DD001304University of North Carolina Clinical Nutrition Research Center
6 · The paper itself

Abstract

objectiveTo investigate associations between maternal periconceptional (three months prior through the third pregnancy month) myo-inositol intake and the odds of selected congenital heart defects in offspring.

designA population-based case-control study using the National Birth Defects Prevention Study (NBDPS) database.

settingUnited States. POPULATION OR SAMPLE: Women with singleton live births without major birth defects (controls) and women with singleton live births, stillbirths, or terminations with selected nonsyndromic congenital heart defects (CHD; cases).

methodsDescriptive analyses, logistic regression models, ascertainment of myo-inositol intake from supplements and food using a shortened food frequency questionnaire and survey.

main outcome measuresOdds of CHD.

results11 752 cases and 11 415 controls were included. Compared to women not taking myo-inositol supplements, women with any supplemental intake were less likely to have a pregnancy with the selected congenital heart defects as a group (adjusted odds ratio [aOR] = 0.79; 95% confidence interval [CI] 0.66-0.94) or with septal defects alone (aOR = 0.61; 95% CI 0.46-0.81). Compared to women with low total myo-inositol intake from food or supplements, women with high total myo-inositol intake (≥ 500 mg/day) were less likely to have a pregnancy with the selected CHD as a group (aOR = 0.88; 95% CI 0.84-0.93) or conotruncal defects (aOR = 0.87; 95% CI 0.79-0.96); left ventricular outflow tract defects (aOR = 0.87; 95% CI 0.78-0.96); right ventricular outflow tract defects (aOR = 0.85; 95% CI 0.77-0.95); or atrial septal defects (aOR = 0.91; 95% CI 0.83-0.99).

conclusionsAn inverse association was observed between maternal myo-inositol intake during the periconceptional period and the odds of selected CHDs in offspring.

Indexed as

Dietary SupplementsHeart Defects, CongenitalInositolAdultCase-Control StudiesFemaleHumansInfant, NewbornLogistic ModelsPregnancyUnited StatesYoung AdultInositolcongenital heart defectsfolic acidmyo‐inositol

Identifiers

PMID41307476
PMCPMC12770076

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.