Trial reportClinical nephrology2025
Measurement of ionized calcium with a point-of-care ionometer during etelcalcetide therapy.
Trial report in Clinical nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
introductionHypocalcemia is a common and clinically significant side effect of etelcalcetide therapy. The aim of this study was to evaluate the utility of ionized calcium (iCa) measurements with a point-of-care ionometer compared to albumin-corrected total calcium and to assess the incidence of hypocalcemia in patients receiving etelcalcetide therapy using pre-dialysis iCa values. MATERIALS AND
methodsThis was a phase IV, non-interventional, prospective, single-arm, observational study. A total of 20 chronic hemodialysis patients were included in the study. The iCa concentration was determined before dialysis using a point-of-care ionometer (GEM Premier 3000) at the patient's bedside. Hypocalcemia was defined by a pre-dialysis iCa concentration of less than 0.90 mmol/L.
resultsPre-dialysis corrected total calcium and iCa decreased over time during treatment with etelcalcetide. A statistically significant linear association was observed between point-of-care iCa and albumin-corrected calcium (r = 0.532, p = 0.019; R
conclusionOur results highlight the value of direct iCa monitoring as a practical and sensitive tool for detecting hypocalcemia and guiding etelcalcetide therapy. Bedside measurement enabled timely dialysate calcium adjustments, preventing clinically significant hypocalcemia and treatment discontinuation. Point-of-care iCa monitoring offers a safer, more responsive strategy for optimizing calcium management in hemodialysis patients.
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