Evidence map›Paper›PMID 41307412›Full record

ArticleClinical nephrology2025

Metabolic health in the Slovenian national cohort of kidney transplant patients.

Gregor Mlinšek, Anja Ponikvar Ležaić, Petra Finderle, Miha Arnol

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Article in Clinical nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Gregor Mlinšek
Anja Ponikvar Ležaić
Petra Finderle
Miha Arnol

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMetabolic health refers to the proper functioning and balance of metabolic processes in our bodies. The metabolism of carbohydrates, lipids, and proteins has a direct impact on the cardiovascular system. Recent advances in pharmacotherapy have introduced several drugs into clinical practice that can improve cardiometabolic health. MATERIALS AND

methodsBetween September 2023 and March 2024, we systematically collected cardiometabolic data from 800 kidney transplant patients (KTPs) during their routine outpatient visits. These included clinical data - office blood pressure, body weight and height, body mass index (BMI), and waist circumference (WC) - and laboratory data such as high-sensitivity C-reactive protein (hs-CRP), lipid profile, lipoprotein(a) (Lp(a)), glycated hemoglobin (HbA1c), serum urate, serum albumin, and proteinuria from spot urine samples. Patients who required treatment adjustment were selected.

resultsDeviations from the desired values of individual components of the metabolic syndrome (blood pressure, WC, triglycerides, high-density lipoprotein cholesterol, and fasting glucose) were observed in 23 - 61.5% of patients. Elevated hs-CRP levels (5 - 10 mg/L), a known cardiovascular risk factor, were observed in 13.5% of patients. Lp(a) levels exceeded the upper normal limit (> 500 mg/L) in 17% of patients. Only a small proportion of patients with moderate to advanced kidney disease - 13% and 23.6%, respectively - had low-density lipoprotein cholesterol levels within the reference range.

conclusionsBetween 23% and 61.5% of patients failed to meet target values for individual components of metabolic health. The largest deviation (61.5%) was observed in WC among women. WC and waist-to-height ratio are two simple and reliable parameters for assessing metabolic status.

Indexed as

Kidney TransplantationMetabolic SyndromeAdultAgedBlood GlucoseBlood PressureBody Mass IndexCohort StudiesC-Reactive ProteinFemaleHumansMaleMiddle AgedSloveniaWaist CircumferenceBlood GlucoseC-Reactive Protein

Identifiers

PMID41307412
PMCPMC12912640

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