ArticleAngewandte Chemie (International ed. in English)2026
Membrane-Penetrating Molecular Device Based on a Triplex Containing Acyclic L-Threoninol Nucleic Acid Functionalized with Cholesterol.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Omega Nucleic Acids (ΩNA), Ultimate Nucleic Acids for Future Technology.Molecules (Basel, Switzerland) · 2026Review
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3 authors.
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Abstract
Membrane-penetrating molecular devices are valuable biological tools. Herein, we describe membrane-targeting molecular devices based on the triplexes of poly T acyclic L-threoninol nucleic acid (L-aTNA) tethered site-specifically to cholesterol and poly A DNA. The L-aTNA was linked to cholesterol in two different orientations. The membrane-binding properties differed depending on the orientation at the cholesterol linkage. One triplex adhered to giant unilamellar vesicles and the other penetrated these vesicles. When the membrane-penetrating triplex was formed with a photoresponsive DNA, photoresponsive signal transduction into giant unilamellar vesicles was enabled. These membrane-targeting molecular devices have potential as biosensors, artificial organs, and molecular robots and in chemical artificial intelligence. Moreover, this strategy for post-modification of the propargyl-L-aTNA unit will enable further functionalization of L-aTNA and other acyclic XNAs.
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