Evidence map›Paper›PMID 41307209›Full record

ArticleThe Laryngoscope2026

Multi-Institutional Endoscopic Resection and Reconstitution for Idiopathic Subglottic Stenosis.

Diana C Lopez, Ioan A Lina, Ryan Stepp, James J Daniero, Theresa Hennesy, Matthew Clary, Alexander Gelbard, Alexander T Hillel

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Diana C LopezDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-7055-367X
Ioan A LinaDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ryan SteppDepartment of Otolaryngology-Head and Neck Surgery, University of Virginia, Charlottesville, Virginia, USA.
James J DanieroDepartment of Otolaryngology-Head and Neck Surgery, University of Virginia, Charlottesville, Virginia, USA.
Theresa HennesyDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0003-2082-6830
Matthew ClaryDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
Alexander GelbardDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-0078-1305
Alexander T HillelDepartment of Otolaryngology-Head and Neck Surgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-8471-5449

Funding

Targeting mTOR regulation of T-lymphocytes and fibroblasts in Laryngotracheal StenosisR01DC018567 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI HILLEL, ALEXANDER · 2020 to 2024
$3.8M
Translating a biostimulatory implant for the long-term treatment of glottic insufficiencyR01DC020998 · NIDCD · UNIVERSITY OF VIRGINIA · PI James J. Daniero, Donald Richieri Griffin · 2023 to 2026
$1.9M
E-cadherin deficient epithelium drives airway fibrosis in idiopathic subglottic stenosisR01HL174875 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Alexander Hillel · 2025 to 2026
$1.5M
NHLBI NIH HHS R01 HL174875NIDCD NIH HHS R01 DC018567NIDCD NIH HHS R01 DC020998
6 · The paper itself

Abstract

objectivesEndoscopic resection and mucosal reconstitution with epidermal grafting (i.e., ER, known as the Maddern procedure) is a minimally invasive surgery introduced 10 years ago to treat subglottic stenosis (SGS). Here we describe a multi-institutional case series to answer questions about durability, patient selection, and complications.

methodsA retrospective review of idiopathic SGS patients who underwent ER at four institutions since 2016. Patients were stratified by primary definitive (only had previous dilations) and rescue (performed for recurrence after laser wedge resection, open surgery, or previous ER) procedures. Outcomes included complications, disease recurrence, need for tracheostomy, peak expiratory flow rates, and surgery-free period following the operation.

resultsThirty-six ER procedures were performed in 33 females and 1 male. Average participant age was 49 (30-72) years and BMI 28.5 (19.1-41.5) kg/m

conclusionThis multi-institutional series demonstrates that the minimally invasive ER procedure, when used as primary definitive surgery, provides durable outcomes for iSGS with a recurrence rate similar to that of open cricotracheal resection over the course of an 8-year follow-up period. LEVEL OF EVIDENCE: 4:

Indexed as

LaryngoscopyLaryngostenosisAdultAgedFemaleHumansMaleMiddle AgedPostoperative ComplicationsRecurrenceRetrospective StudiesTracheostomyTreatment Outcomeendoscopic resectionMaddernmucosal reconstitutionsubglottic stenosis

Identifiers

PMID41307209
PMCPMC12668226

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.