SynthesisJournal of cosmetic dermatology2025
Optimizing Rhinoplasty Outcomes: The Role of Isotretinoin and Patient Management Strategies: Systematic Review.
Synthesis in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Optimizing Rhinoplasty Outcomes: The Role of Isotretinoin and Patient Management Strategies: Systematic Review.Journal of cosmetic dermatology · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRhinoplasty outcomes in patients with thick nasal skin may be challenging due to the sebaceous nature of the skin, which can compromise tip definition and delay resolution of postoperative edema. Perioperative adjunct using isotretinoin is suggested as a well-established treatment for acne and sebaceous hyperactivity.
methodsWe conducted this systematic review in accordance with PRISMA guidelines. Literature searches were performed in PubMed, Scopus, Web of Science, and Embase databases for studies published up to March 2025. Search strategies incorporated combinations of keywords relating to "rhinoplasty," "isotretinoin," "nasal skin," and "wound healing." Eligible studies included randomized controlled trials (RCTs), cohort and retrospective studies, with human participants undergoing rhinoplasty with or without systemic or topical isotretinoin, reporting on outcomes such as skin thickness, edema, patient satisfaction, wound healing, and complications. Risk of bias and quality assessment were assessed with the Joanna Briggs Institute (JBI) critical appraisal tools.
resultsThis systematic review included seven eligible studies-all with human participants-three RCTs, three retrospective cohort studies, and one prospective cohort study. We found that isotretinoin improved nasal tip definition, decreased postoperative edema, and improved patient satisfaction. Specific studies reported a marked reduction in sebaceous gland activity, and shaved-off nasal skin thickness was considered responsible for the more refined aesthetic outcome. No significant adverse effects other than mild mucosal dryness and transient cheilitis were observed; it seemed to accelerate wound healing. However, causality within isotretinoin use could not be established in some studies, and some needed revision surgery.
conclusionIsotretinoin administration, particularly when individualized by patient profile, appears to significantly improve both aesthetic and wound-healing outcomes in rhinoplasty patients with thick nasal skin and displays a favorable safety profile under close monitoring. Further large-scale RCTs are required to optimize dosage and perioperative protocols.
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