ArticleAdvanced biomedical research2025
Melatonin Reduces Radiation-induced Apoptosis Through Change of bax and bcl-2 Expression in Peripheral Blood Lymphocytes.
Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The most important harmful effect of ionizing radiation is the production of free radicals. A correlation was demonstrated between free radicals and apoptosis. Melatonin might be a direct free radical scavenger. Melatonin's ability to modify the expression of bcl-2 and bax and apoptosis in peripheral blood lymphocytes in rats was studied. Materials and Methods: Rats received one total-body x-radiation dosage of 2 Gy either with or without prior treatment of melatonin at a dosage of 100 mg/kg body weight. The animals were grouped as follows: VC control (VC), 2 Gy irradiation (RT), 100 mg/kg melatonin + 2 Gy irradiation (MLT + RT), and 100 mg/kg melatonin (MLT). Animals were given intraperitoneal melatonin or an identical amount of vehicle alone 1 hour before radiation. Blood samples were collected 4, 24, and 72 hours after radiation to evaluate apoptotic lymphocytes through flow cytometric analysis using the Annexin V/PI assay, as well as to measure bcl-2 and bax expression via quantitative real-time PCR. Results: An elevation was noted in the RT group in the percentage of apoptotic lymphocytes compared to the VC group ( Conclusion: Melatonin can protect rat lymphocytes from x-radiation-triggered apoptosis by modulating bcl-2 and bax expression. Therefore, melatonin could serve as a potential radio-protective agent, making it a candidate for use alongside radiation in clinical trials.
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