ArticleAdvanced biomedical research2025
Pantoprazole Inhibited Metastasis and Angiogenesis Through Wnt/
Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- SMARCD1 and Its Functional Relevance in SWI/SNF and Cancer.International journal of molecular sciences · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The research on different therapy approaches is critical to find an efficient gastric cancer treatment. The processes of new drug production are very expensive and also take about 15 years. Therefore, the use of existing drugs for treating new diseases may be beneficial in pharmaceutical biotechnology. Thus, we investigated the influence of pantoprazole on Wnt signaling pathway, metastasis, stemness markers, and Materials and Methods: GCSCs were isolated from MKN-45 cells on a nonadhesive surface. Cell viability, angiogenesis, metastasis, and transcription of Results: Our findings represented that pantoprazole decreased the cell viability, angiogenesis, metastasis, and stemness features of GCSCs. Also, pantoprazole had an inhibitory impact on Wnt signaling pathway by modulating the transcription level of Conclusions: We showed that pantoprazole may reduce the tumorigenicity of GCSCs through the Wnt signaling pathway. Therefore, pantoprazole may be an assistance treatment for gastric cancer therapy.
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