Evidence map›Paper›PMID 41306923›Full record

ArticleMaterials today (Kidlington, England)2025

Aptamers in Drug Delivery Development.

Connie Wen, Yixun Wang, Yong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today (Kidlington, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Connie WenDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
Yixun WangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
Yong WangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.

Funding

Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous HydrogelR01GM154105 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Yong Wang, Na Xiong · 2024 to 2026
$1.4M
Non-covalent functionalization of collagen for growth factor delivery using bispecific aptamersR01EB035568 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI Yong Wang · 2024 to 2026
$1.3M
NIBIB NIH HHS R01 EB035568NIGMS NIH HHS R01 GM154105
6 · The paper itself

Abstract

Aptamers, often described as "chemical antibodies", are short, single-stranded nucleic acids that can bind target molecules with high affinity and specificity. Due to these properties, aptamers have diverse therapeutic applications. They can function as standalone drugs, serve as carriers for a range of therapeutics including small molecules, nucleic acids, peptides, proteins, and antibodies, or be used to functionalize drug delivery systems such as nanoparticles and bulk biomaterials. This review summarizes these diverse applications and discusses potential challenges associated with aptamers and drug delivery systems more broadly.

Indexed as

AptamerDrug DeliveryHydrogelsNanoparticles

Identifiers

PMID41306923
PMCPMC12646516

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.