Evidence map›Paper›PMID 41306903›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Calcium hydroxide coating for orthopedic implants: evaluation of osseointegrative and antibacterial properties

Sebastian Philipp von Hertzberg-Boelch, Andrea Ewald, Markus Meininger, Julia Ludwig, Fabian Vogt, Jürgen Groll, Maximilian Rudert

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Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sebastian Philipp von Hertzberg-Boelch *Department of Orthopaedic Surgery, University of Wuerzburg, Wuerzburg, Germany.
Andrea Ewald *Department for Functional Materials in Medicine and Dentistry, University of Wuerzburg, Wuerzburg, Germany.
Markus MeiningerDepartment for Functional Materials in Medicine and Dentistry, University of Wuerzburg, Wuerzburg, Germany.
Julia LudwigDepartment for Functional Materials in Medicine and Dentistry, University of Wuerzburg, Wuerzburg, Germany.
Fabian VogtDepartment for Functional Materials in Medicine and Dentistry, University of Wuerzburg, Wuerzburg, Germany.
Jürgen GrollDepartment for Functional Materials in Medicine and Dentistry, University of Wuerzburg, Wuerzburg, Germany.
Maximilian RudertDepartment of Orthopaedic Surgery, University of Wuerzburg, Wuerzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: We evaluated the osseointegrative and antibacterial properties of calcium hydroxide-coated titanium implants in this study and compared them to uncoated implants in a rabbit model. Methods: Coated and uncoated implants were implanted into both femora of 19 New Zealand white rabbits. After retrieval, the osseointegrative properties were compared via quantification of bone-implant contact and proportion of unmineralized bone around the implant; further, the antibacterial properties were assessed using a Results: The bone-implant contact was significantly higher ( Conclusion: Calcium hydroxide is a promising coating for titanium implants. Our animal study demonstrates the improved osseointegrative properties and evidences the topical antibacterial effects of coated implants.

Indexed as

antibacterial implant coatingbone–implant contactimplant osseointegrationinfection modelperiprosthetic infection

Identifiers

PMID41306903
PMCPMC12644090

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.