ArticleInternational journal of trichology
Prepubertal Fibrosing Alopecia in a Pattern Distribution.
Article in International journal of trichology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Fibrosing alopecia in a pattern distribution (FAPD) is a cicatricial alopecia characterized by an androgenetic alopecia (AGA)-like pattern hair loss (PHL) associated with a lichen planopilaris (LPP)-like infiltrate on histopathology. Prepubertal PHL is the term proposed for AGA in children. The pattern is exclusively that of female PHL. We report the first case of FAPD in a child with prepubertal PHL. A 9-year-old girl initially presented with chronic itching, redness, and scaling of the central scalp area, which eventually developed to a cicatricial PHL with histopathological evidence of LPP. The implication of a follicular microinflammation and fibrosis associated with AGA has emerged from several studies. Ultimately, Zinkernagel and Trüeb reported a peculiar cicatricial PHL with histopathological features of LPP and named it FAPD. So far, FAPD has only been observed in adults. The observation of FAPD in a child with prepubertal PHL suggests that the condition is not androgen dependent and may explain the limited efficacy of 5-alpha reductase inhibitors for treatment of FAPD. The primary aims for treatment are anti-inflammatory in combination with a hair growth-promoting agent such as minoxidil.
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