Evidence map›Paper›PMID 41306797›Full record

ArticleContact in context2025

NIR Spectrometry Reveals Lack of Content Uniformity in Methylprednisolone Sodium Succinate.

James T Isaacs, Philip J Almeter, Eleonora Hasani, Aaron N Hunter, Thomas A Lyman, Stephanie P Zapata, Bradley S Henderson, Seth A Larkin, Uiyeol Yoon, Adler Crumrin and 11 more

Abstract read
In one paragraph

Article in Contact in context, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

James T IsaacsDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Philip J AlmeterDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Eleonora HasaniDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Aaron N HunterDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Thomas A LymanDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Stephanie P ZapataDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Bradley S HendersonDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Seth A LarkinDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Uiyeol YoonDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Adler CrumrinDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Jerod SmithDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Spencer PergremDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Ashton PlymaleDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Bailee RamnesDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Reagan KnightDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Erin VongchanDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Samantha SchnabelDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Madison GeibDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Abby WingateDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Ryan W NasemanDepartment of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY 40536.
Robert A LodderDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536.ORCID 0000-0001-6133-7561

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
NCATS NIH HHS UL1 TR001998
6 · The paper itself

Abstract

Methylprednisolone sodium succinate for injection, USP is an anti-inflammatory glucocorticoid. The active ingredient is methylprednisolone sodium succinate, which is the sodium succinate ester of methylprednisolone. The substance is a white or nearly white, odorless, hygroscopic, amorphous solid. It is highly soluble in water and alcohol, insoluble in chloroform, and only slightly soluble in acetone. This injectable form of the drug is indicated for the treatment of various conditions, including some allergic states, dermatologic, endocrine, gastrointestinal, hematologic, neoplastic, nervous system, ophthalmic, renal, respiratory, and rheumatic disorders. The analysis of a single lot of methylprednisolone sodium succinate revealed significant intra-lot variability in the near-infrared spectra. Differences were visually apparent in the absorbance peaks, particularly in the ranges of 4500 to 5000 cm

Identifiers

PMID41306797
PMCPMC12646679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.