Evidence map›Paper›PMID 41306782›Full record

ArticleFrontiers in pharmacology2025

Accidental cannabis intoxication in two young children: clinical presentation and toxicokinetics - a case series.

Alessia Cafaro, Federica Pigliasco, Sebastiano Barco, Ilaria Negro, Emanuela Piccotti, Luca Manfredini, Samir Mahameed, Roberto Bandettini, Carla Debbia, Francesca Mattioli and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alessia CafaroBiochemistry, Pharmacology and Newborn Screening Unit, Central Laboratory of Analysis, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Federica PigliascoBiochemistry, Pharmacology and Newborn Screening Unit, Central Laboratory of Analysis, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Sebastiano BarcoBiochemistry, Pharmacology and Newborn Screening Unit, Central Laboratory of Analysis, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Ilaria NegroPediatric Emergency Room and Emergency Medicine, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Emanuela PiccottiPediatric Emergency Room and Emergency Medicine, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Luca ManfrediniPediatric Pain and Palliative Care Service, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Samir MahameedDepartment of Internal Medicine, Pharmacology & Toxicology Unit, University of Genoa, Genoa, Italy.
Roberto BandettiniBiochemistry, Pharmacology and Newborn Screening Unit, Central Laboratory of Analysis, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Carla DebbiaPediatric Emergency Room and Emergency Medicine, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Francesca Mattioli *Department of Internal Medicine, Pharmacology & Toxicology Unit, University of Genoa, Genoa, Italy.
Giuliana Cangemi *Biochemistry, Pharmacology and Newborn Screening Unit, Central Laboratory of Analysis, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accidental exposure to edible cannabis products in children is an increasing public health concern. The clinical presentation is often nonspecific, which can delay diagnosis and lead to inappropriate management. Toxicological screening is therefore essential for accurate diagnosis and appropriate treatment. We report the toxicokinetic (TK) profiles of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) following unintentional ingestion of cannabis in two pediatric cases, aged 12 and 15 months, respectively. Plasma concentrations of THC and CBD were measured using a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. THC was consistently detected in all plasma samples collected (four per patient), with highest measured concentrations of 45.0 μg/L in Case 1 and 54.7 μg/L in Case 2. CBD was not detected in Case 1, whereas in Case 2 it was measurable only in the first plasma sample, at a concentration of 1.11 μg/L. Non-compartmental analysis (NCA) of the THC concentration-time data enabled calculation of the TK profiles in both cases. The elimination rate constant (k

Indexed as

cannabischildrenintoxicationpharmacokineticstoxicokinetic

Identifiers

PMID41306782
PMCPMC12644977

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.