ArticleInternational journal of reproductive biomedicine2025
Impact of platelet-rich plasma at different concentrations on genes of apoptotic pathway and differentiation of stem cells in cyclophosphamide-induced ovarian failure in a mouse model: An experimental study.
Article in International journal of reproductive biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Platelet-rich plasma and folliculogenesis: a systematic mechanistic review and computational pathway analysis.Frontiers in reproductive health · 2026Pooled it
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Platelet-rich plasma (PRP), a new therapeutic technique, has the potential to regenerate failing ovarian tissue and alleviate symptoms in patients with premature ovarian failure (POF). Objective: This study examined the effect of different platelet concentrations on ovarian function, investigated the apoptosis genes B-cell lymphoma 2 ( Materials and Methods: In this experimental study, 30 female Syrian mice (8-10 wk, 25-30 gr) were randomly divided into 5 groups (n = 6/each): 1) normal control, 2) POF + phosphate buffered saline, 3) POF + PRP 0.25 ml/kg, 4) POF + PRP 0.5 ml/kg, and 5) POF + PRP 1 ml/kg. The cyclophosphamide was used to create a mouse model of POF. After 2 wk from injection of PRP and phosphate buffered saline, ovaries were removed for histological and molecular analysis. Results: The distribution of different follicle types in the POF + PRP group was the same as that of the control group, according to a morphometric study. Bcl-2-associated X protein gene expression was significantly reduced in the groups that received PRP (p Conclusion: The results showed that PRP can be effective in POF, but different dosages of PRP can have different effects on the recovery of ovarian.
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