ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2025
Impact of multifaceted clinical decision support and education on antibiotic duration in outpatients with respiratory tract infections in Saudi Arabia: a prospective pre- and postimplementation study.
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Prolonged antibiotic therapy is associated with an increased risk of antimicrobial resistance and adverse events. We evaluated the implementation of a multifaceted antimicrobial stewardship (ASP) initiative aimed at reducing antibiotic duration for respiratory tract infections (RTIs) in outpatient settings. Designs: Quasi-experimental study. Settings: Academic medical center in Riyadh, Saudi Arabia. Patients: Patient with RTIs in outpatient settings. Methods: A multifaceted ASP intervention-including a clinical decision support tool and an educational session-was implemented to guide physicians in prescribing the shortest effective duration of oral antibiotics. We compared antibiotic utilization and adherence to evidence-based duration prescribing in a preintervention phase (June 2021-December 2021) and a postintervention phase (January 2022-June 2022) . Results: We included 2320 patients in our study, of which 1359 were in the preintervention period and 961 in the postintervention period. Following implementation of the multifaceted stewardship initiative, the days of therapy (DOT) per 1,000 outpatient visits decreased from 131 to 50 and the mean duration of antibiotic therapy declined from 6.4 to 6.0 days ( Discussion: The multifaceted ASP initiative can reduce unnecessary antibiotic exposure and improve the adherence to the recommended duration.
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