Evidence map›Paper›PMID 41306706›Full record

ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2025

Impact of switching from polymerase chain reaction-only to two-step

Sapana R Gupta, Tyler M Selig, Kathryn Evey, Michael Rossi, Adam M Burton, Curtis Petruzzelli, Jacqueline J Chu, Wen Ting Yang, James Scharfen, Joshua Ray Tanzer and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sapana R GuptaDepartment of Medicine, Brown University Health, Providence, RI, USA.ORCID https://orcid.org/0000-0002-8597-5776
Tyler M SeligDivision of Gastroenterology, Stony Brook University Hospital, Stony Brook, NY, USA.ORCID https://orcid.org/0000-0002-0443-9972
Kathryn EveyDepartment of Medicine, Brown University Health, Providence, RI, USA.ORCID https://orcid.org/0000-0001-6701-611X
Michael RossiDepartment of Medicine, Brown University Health, Providence, RI, USA.ORCID https://orcid.org/0009-0001-2316-8952
Adam M BurtonDepartment of Medicine, Brown University Health, Providence, RI, USA.ORCID https://orcid.org/0000-0002-5137-1181
Curtis PetruzzelliDepartment of Medicine, Brown University Health, Providence, RI, USA.
Jacqueline J ChuDepartment of Medicine, Brown University Health, Providence, RI, USA.
Wen Ting YangDepartment of Medicine, Brown University Health, Providence, RI, USA.
James ScharfenDivision of Gastroenterology, Icahn School of Medicine at Mount Sinai Morningside/West, New York, NY, USA.ORCID https://orcid.org/0000-0002-8183-9291
Joshua Ray TanzerDepartment of Medicine, Brown University Health, Providence, RI, USA.
John R LonksDepartment of Medicine, Brown University Health, Providence, RI, USA.ORCID https://orcid.org/0009-0004-4395-0679
Colleen R KellyDivision of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.ORCID https://orcid.org/0009-0005-8176-2393

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: A retrospective cohort study of 2,173 adult inpatients was conducted. Patients were grouped into two cohorts: those tested for toxigenic Results: In the moderate-risk group, there was a significant reduction in ICU transfers and readmission rates with the two-step testing by 5% and 7%, respectively. There were no other significant differences in complications between testing groups. Anti-CDI antibiotics were discontinued in 15% ( Discussion: The two-step testing algorithm did not negatively affect patient outcomes and led to a modest decrease in anti-CDI treatment, supporting the safety of two-step CDI testing in hospitalized patients.

Identifiers

PMID41306706
PMCPMC12645233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.