Evidence map›Paper›PMID 41306699›Full record

ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2025

Antifungal use and appropriateness: a study of Australian Hospital National Antimicrobial Prescribing Survey data.

Anna Khanina, Nikhil Singh, Josephine Wen, Caroline Chen, Rodney James, David Cm Kong, Monica A Slavin, Karin A Thursky

Abstract read
In one paragraph

Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna KhaninaThe National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID https://orcid.org/0000-0003-2988-1676
Nikhil SinghThe National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Josephine WenThe National Centre for Antimicrobial Stewardship, Department of Infectious Diseases, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Caroline ChenThe National Centre for Antimicrobial Stewardship, Department of Infectious Diseases, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID https://orcid.org/0000-0002-9512-0448
Rodney JamesThe National Centre for Antimicrobial Stewardship, Department of Infectious Diseases, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
David Cm KongThe National Centre for Antimicrobial Stewardship, Department of Infectious Diseases, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Monica A SlavinThe National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID https://orcid.org/0000-0002-8443-314X
Karin A ThurskyThe National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID https://orcid.org/0000-0002-7400-232X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To evaluate the quality of systemic antifungal prescribing in Australian hospitals using point-prevalence survey data from the Hospital National Antimicrobial Prescribing Survey (Hospital NAPS). Methods: Data were extracted from the Hospital NAPS dataset from January 2014 to December 2024. Systemic antifungal prescriptions were analyzed for antifungal use, guideline compliance, appropriateness, and reasons for inappropriateness according to the Hospital NAPS methodology. Demographic factors, hospital classifications, antifungals, and antifungal indication were compared. Results: A total of 7,830 systemic antifungal prescriptions from 372 healthcare facilities across all Australian states and territories were included. Overall 88.4% were guideline compliant and 92.3% of prescriptions were deemed appropriate. Fluconazole was the most commonly prescribed antifungal but had one of the lowest percentage appropriateness (88.4%). In contrast, mold-active azoles, echinocandins, and amphotericin B demonstrated appropriateness rates exceeding 90%. Prescriptions with approval through local antimicrobial stewardship (AMS) processes had significantly higher appropriateness than those without (95.9% vs. 82.9%, Conclusion: This national evaluation highlights the overall high quality of systemic antifungal prescribing in Australian hospitals, reflecting the strength of AMS programs. However, variation across hospital types, specialties, and antifungal agents-particularly fluconazole-indicates opportunities for targeted stewardship interventions to further optimize antifungal use.

Identifiers

PMID41306699
PMCPMC12645246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.