SynthesisInternational journal of nanomedicine2025
Advances in the Application of Multimodal Nano-Antimicrobial Strategies in Prosthetic Joint Infections: A Systematic Review.
Synthesis in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- ["Chongqing experiences" in treatment of bone infections].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Hydrogel-based strategies for periprosthetic joint infection: from osteoimmune mechanisms to clinical translation.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Prosthetic joint infection (PJI), a severe complication following total joint arthroplasty, is characterized by prolonged treatment duration, high costs, and poor outcomes. Current clinical treatment which typically relies on the use of antibiotic-loaded bone cement (ALBC) is limited by the generalization of bacterial resistance and the inherent defects of bone cement. Advancements in nanotechnology have led to nanomaterials and nanocoatings that offer promising alternative strategies, showing great potential for the prevention and management of PJI. This review aims to summarize the applications of nanotechnology in preventing and treating PJI following total joint arthroplasty and further discuss current advances and future perspectives in this field. Methods: PubMed, Web of Science, Scopus and Embase were searched for relevant studies covering the period from their inception to June 12, 2025. After removal of duplicate records, studies were excluded based on their abstract and title. The remaining studies were assessed for eligibility based on their full-text content. Conclusion: Nanotechnology has emerged as a highly promising alternative strategy against PJI. The current research frontiers encompass not only the development of stimulus-responsive nanomaterials for precise antibacterial control but also exploring their integration with targeted therapies, immunotherapy, and piezoelectric-based therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.