ArticleMalawi medical journal : the journal of Medical Association of Malawi2025
Effect of Hepatitis C Virus Infection on Liver Function, T Cell Immunity, and Mortality Risk in Maintenance Hemodialysis Patients.
Article in Malawi medical journal : the journal of Medical Association of Malawi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This retrospective study explored the clinical impact of hepatitis C virus (HCV) infection in maintenance hemodialysis (MHD) patients through comprehensive analysis of liver/renal function parameters, cellular immunity profiles, and long-term survival outcomes. Methods: The study enrolled 28 HCV-infected MHD patients (MHD-HCV group), 28 HCV-negative MHD patients (MHD group), and 21 healthy controls (NC group) retrospectively. Liver and renal functions, lymphocyte subset analysis, and interleukin-10 (IL-10) levels were assessed. Overall survival at a median follow-up of 4 years was compared between the MHD-HCV and MHD groups. Results: Biochemical analysis demonstrated significantly elevated liver enzymes in the MHD-HCV group compared to MHD group, with mean alanine aminotransferase (ALT) levels of 26.6 ± 18.6 vs. 10.1 ± 7.1U/L ( Conclusion: HCV infection in MHD patients leads to non-negligible liver dysfunction, elevated Tregs and IL-10, as well as higher mortality.
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