Mouse Vestibulo-Ocular Reflex Testing for Otolith Organs and Horizontal Semicircular Canal.

Tong Zhao, Shijie Xiao, Qingsong Liu, Jinxuan Liu, Fangyi Chen

Abstract read

In one paragraph

Article in Bio-protocol, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tong ZhaoDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.

Shijie XiaoDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.

Qingsong LiuDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.

Jinxuan LiuGiant Technologies Co., Ltd, Shenzhen, China.

Fangyi ChenDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vestibulo-ocular reflexes (VORs) are compensatory ocular reflexes that maintain stable vision during head movements. In research, VORs encompass angular VOR (aVOR) and off-vertical axis rotation (OVAR) tests, which various groups have employed to assess vestibular function in mice. This protocol outlines the process for measuring VORs in mice, including eye rotation calibration, immobilizing the mouse with a noninvasive setup, configuring the aVOR and OVAR stimulus modes, and interpreting the obtained waveforms to derive VOR values. As technology advances, VORs are expected to yield more qualitative and quantitative insights into the function of the horizontal semicircular canal cristae (HSCC) and the otolith organs. This methodology can serve as a standard for evaluating common vestibular deficits in mice. Key features • The integrated aVOR and OVAR modes enable us to evaluate both the otolith organs and horizontal semicircular canals. • The calibration tools used in our system ensure standardization between different systems, facilitating comparison of results between laboratories. • Animal holders provide a rapid and convenient method for conducting VOR tests without the need for anesthesia or surgery.

Indexed as

Comprehensive mouse vestibular function evaluationOff-vertical axis rotation (OVAR)Otolith organSemicircular canalsVestibulo-ocular reflexes (VORs)

Identifiers

PMID41306583

DOI10.21769/BioProtoc.5509

PMCPMC12645213

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.