Evidence map›Paper›PMID 41306553›Full record

ArticlePNAS nexus2025

Integrating omics and functional data via representation learning to prioritize candidate genes for pleiotropic effect in dairy sheep.

Pablo Augusto de Souza Fonseca, Aroa Suárez-Vega, Laura Casas, Hector Marina, Beatriz Gutiérrez-Gil, Juan Jose Arranz

Abstract read
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pablo Augusto de Souza FonsecaInstituto de Ganadería de Montaña (CSIC-Univ. de León), Finca Marzanas, Grulleros, 24346 León, Spain.ORCID https://orcid.org/0000-0002-6917-7475
Aroa Suárez-VegaDpto. Producción Animal, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24007 León, Spain.ORCID https://orcid.org/0000-0002-7726-4288
Laura CasasAssafe, National Assaf Sheep Breeders Association, Granja Florencia, Toro, 49800 Zamora, Spain.
Hector MarinaDpto. Producción Animal, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24007 León, Spain.ORCID https://orcid.org/0000-0001-9226-2902
Beatriz Gutiérrez-GilDpto. Producción Animal, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24007 León, Spain.ORCID https://orcid.org/0000-0001-7990-5723
Juan Jose ArranzDpto. Producción Animal, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24007 León, Spain.ORCID https://orcid.org/0000-0001-9058-131X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global demand for improved productivity, sustainability, welfare, and quality in livestock production presents significant challenges for breeders. Understanding trait correlations, often driven by pleiotropy, is essential for simultaneously improving traits of economic interest. Integrating multi-omics data and functional annotations can improve the disentangling of biological processes underlying the pleiotropic effect. Network-based machine learning (ML) models offer a robust solution for this integration. This study estimated gene-level

Indexed as

dairy sheepgenetic correlationmachine learningomics integrationpleiotropy

Identifiers

PMID41306553
PMCPMC12646080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.