Trial reportFrontiers in medicine2025
Effect of dural puncture epidural combined with programmed intermittent epidural bolus on labor analgesia in patients with gestational hypertension: a randomized controlled clinical trial.
Trial report in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Hypertensive disorders of pregnancy affect 5-10% of pregnancies and require the maintenance of hemodynamic stability while providing effective labor analgesia. This study compared the efficacy and safety of dural puncture epidural (DPE) block combined with programmed intermittent epidural bolus (PIEB) versus conventional epidural (EP) block in labor analgesia for patients with gestational hypertension (GH). Methods: Between January and March 2025, 98 primiparous women with GH and singleton pregnancies who requested neuraxial analgesia were randomized to receive either DPE-PIEB (Group D, Results: Compared with EP-PIEB, patients receiving DPE-PIEB had a shorter onset of analgesia (6.05 ± 1.08 vs. 9.75 ± 1.3 min, Conclusion: DPE-PIEB can significantly shorten the onset of labor analgesia in patients with GH, reduce hemodynamic fluctuations and breakthrough pain, and improve maternal satisfaction, without increasing maternal or neonatal risks. This combined technique provides a more optimized analgesic strategy and can be safely and effectively implemented in labor analgesia for patients with GH. Clinical trial registration: Identifier ChiCTR2400095084 (www.chictr.org.cn).
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