ArticleFrontiers in medicine2025
A risk prediction model of spontaneous miscarriage in women with threatened miscarriage: a prospective cohort study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association of the Salivary Progesterone-to-Estradiol Ratio with Threatened Miscarriage.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: This study aims to develop a holistic risk prediction triage tool for women with threatened miscarriage by integrating clinical, biochemical, and radiological factors. Additionally, we aim to assess the performance of various models incorporating different factor combinations, adaptable for diverse resource settings. Methods: This prospective cohort study included 1,080 women with single intrauterine pregnancies at 5-12 weeks' gestation presenting with threatened miscarriage at KK Women's and Children's Hospital, Singapore between October 2017 and May 2023. Multivariable logistic regression and risk-score models were developed using maternal age, nausea, prior miscarriages, serum progesterone, gestational age, and fetal heart activity. Model performance was assessed via Area Under Receiver Operating Characteristic (AUROC) curve with 10-fold cross-validation. The primary outcome was miscarriage by 16 weeks. Results: The miscarriage rate was 17.3%. Low serum progesterone (< 35 nmol/L) was the strongest predictor [odds ratio (OR) 26.3; 95% confidence interval (CI): 16.6-41.5], followed by absent fetal heart detection (OR 4.05; CI: 2.37-6.92) and increasing maternal age (OR 1.05; CI: 1.00-1.11). Higher gestational age decreased miscarriage risk (OR 0.57; CI: 0.45-0.73). The integrated model demonstrated high predictive accuracy (AUROC 0.90; CI: 0.87-0.93). The risk-score model achieved AUROC 0.82, with 80% sensitivity and 84% specificity at cut-off of 2. Discussion: This clinically practical holistic prediction tool enables early identification of women at high risk of miscarriage following threatened miscarriage. It may guide personalized counseling and targeted interventions in both high- and low-resource settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.