Evidence map›Paper›PMID 41306464›Full record

ArticleInternational journal of reproductive biomedicine2025

N-terminal pro-B-type natriuretic peptide levels in pregnant women with heart disease and complications: A cohort study.

Zahra Hatamian, Seyede Houra Mousavi Vahed, Farveh Vakilian, Hoorak Poorzand, Marzieh Lotfalizade, Nahid Zirak, Hassan Mehrad Majd, Marzieh Nozari, Salmeh Dadgar, Malihe Afiat

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Article in International journal of reproductive biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zahra HatamianDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyede Houra Mousavi VahedDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Farveh VakilianDepartment of Cardiology, Faculty of Medicine, Lung Diseases Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Hoorak PoorzandDepartment of Cardiology, Faculty of Medicine, Vascular and Endovascular Surgery Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Marzieh LotfalizadeDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Nahid ZirakDepartment of Anesthesiology, Faculty of Medicine, Lung Diseases Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Hassan Mehrad MajdDepartment of Medical Genetics and Molecular Medicine, Faculty of Medicine, Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Marzieh NozariDepartment of Midwifery, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
Salmeh DadgarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Malihe AfiatDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Heart diseases affect 1-4% of pregnancies, leading to fetomaternal complications. Brain natriuretic peptide is a key biomarker for assessing cardiac adaptation to pregnancy-related hemodynamic changes. The longer half-life of its terminal fragment, N terminal pro brain natriuretic peptide (NT-ProBNP), increases its diagnostic utility. Objective: This study aimed to evaluate the association between NT-proBNP serum levels and fetomaternal complications in pregnant women with cardiovascular disease. Materials and Methods: A prospective longitudinal study was conducted at the Cardiology and Obstetrics Clinic of Imam Reza hospital, Mashhad, Iran, from July 2019-July 2020. 50 pregnant women in their third trimester with cardiovascular disease (New York Heart Association class 2 or higher) were included. Based on NT-proBNP levels, participants were categorized into normal (n = 37) and elevated (n = 13) groups using a 125 pg/ml cutoff. Fetomaternal complications were assessed and analyzed. Results: Elevated NT-proBNP levels were significantly associated with increased hypertension in the second (p = 0.05) and third (p Conclusion: Elevated NT-proBNP levels are strongly linked to hypertension during pregnancy and low neonatal Apgar scores, highlighting its potential as a predictive biomarker for fetomaternal risk assessment.

Indexed as

Cardiovascular diseaseFetomaternal complications.NT-proBNPPregnancy

Identifiers

PMID41306464
PMCPMC12603576

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