Evidence map›Paper›PMID 41306461›Full record

ArticleInternational journal of reproductive biomedicine2025

Protective effect of chrysin on di (2-ethylhexyl) phthalate-induced toxicity in mice testis: An experimental study.

Zahra Matin Manesh, Hossein Zeinali, Fatemeh Ghanbari, Afsaneh Mafi, Mehdi Goudarzi, Mahdiieh Ghoddoosi, Saeed Hajihashemi, Hamid Heidari

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Article in International journal of reproductive biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Effects of chrysin on Kisspeptin, neurokinin B, and dynorphin neurons andInternational journal of reproductive biomedicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zahra Matin ManeshStudent Research Committee, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
Hossein ZeinaliCellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Fatemeh GhanbariDepartment of Pharmacology, Islamic Azad University, Arak Branch, Arak, Iran.
Afsaneh MafiCellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Mehdi GoudarziMedicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mahdiieh GhoddoosiDepartment of Pathology, Shahid Beheshti Medical Center, Qom University of Medical Sciences, Qom, Iran.
Saeed HajihashemiDepartment of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
Hamid HeidariDepartment of Physiology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Di (2-ethylhexyl) phthalate (DEHP) is one of the environmental contaminants used in plastic objects, causing damage to the reproductive system. Chrysin (CHr) is an effective flavonoid in honey propolis with antioxidant activities. Objective: This study aimed to investigate the possible protective effects of CHr on DEHP-induced testicular toxicity in male mice. Materials and Methods: In this experimental study, 50 male NMRI mice (4-6 wk, 20-30 gr) were randomly divided into 5 groups (n = 10/each); group I and II received normal saline and oil, group III received DEHP, group IV received DEHP and CHr, group V were intact treated with CHr. Testis weights were measured. Serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels were evaluated. Also, sperm characteristics and histological changes of the testis were analyzed. Results: Testis weight was decreased in group receiving DEHP. DEHP also reduced the number of sperms, but the administration of CHr improved them. CHr ameliorated DEHP-induced changes in hormonal levels, especially testosterone (p Conclusion: According to our biochemical and histopathological analyses, DEHP led to severe testicular injury. Our results suggest that CHr, as a free radical scavenger, can decrease tissue damage induced by DEHP, be beneficial in alleviating the toxic effects of DEHP on the male reproductive system, and can also be useful in preventing DEHP effects.

Indexed as

ChrysinDiethylhexyl phthalateGonadal hormonesMice.Sperm count

Identifiers

PMID41306461
PMCPMC12603570

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.