ArticleAddiction neuroscience2025
Methadone and morphine have equivalent analgesic but not reward potency in female mice.
Article in Addiction neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Morphine is a potent opioid analgesic but carries high abuse potential. Some evidence indicates that the opioid methadone, used in maintenance therapy for opioid dependence, also provides analgesia with lower misuse liability, but direct behavioral comparisons of morphine and methadone under matched conditions remain limited. Methods: Dose responses curves for morphine and methadone (0.3-10 mg/kg) were generated in adult female C57BL6/J mice using paradigms to measure reward (conditioned place preference) and analgesia (von Frey and hot plate). Results: Morphine supported a conditioned place preference at all doses tested, while methadone induced a significant place preference at 1 and 10 mg/kg, but not at 0.3 mg/kg. Both opioids increased mechanical and thermal antinociceptive thresholds only at the highest dose tested (10 mg/kg). Conclusions: These findings demonstrate that methadone has a lower reward, but similar analgesic potency compared to morphine in female mice.
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