Evidence map›Paper›PMID 41306411›Full record

ArticleChem2025

Cartilage-Targeting Fluorophores for Early Detection of Arthritis in the NIR-II Window.

Homan Kang, Seung Hun Park, Guliz Ersoy Ozmen, Won Hur, Jason Dinh, Haoran Wang, Vy Nguyen, Sung Ahn, Atsushi Yamashita, Wesley R Stiles and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Homan KangGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Seung Hun ParkGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Guliz Ersoy OzmenDepartment of Chemistry, Molecular Basis of Disease and Center of Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, United States.
Won HurGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Jason DinhGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Haoran WangGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Vy NguyenGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Sung AhnGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Atsushi YamashitaGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Wesley R StilesGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Satoshi KashiwagiGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Kai BaoGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Maged HenaryDepartment of Chemistry, Molecular Basis of Disease and Center of Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, United States.
Hak Soo ChoiGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Funding

Targeting parathyroid glands with novel fluorophores for intraoperative imagingR01CA280968 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Michael Bouvet, Maged M Henary · 2023 to 2026
$2.8M
NCI NIH HHS R01 CA280968
6 · The paper itself

Abstract

Early diagnosis is crucial for the effective treatment of rheumatoid arthritis because continuing inflammation can lead to irreversible joint damage. However, current diagnostic methods lack tissue-specific guidelines to monitor the progressive course of degenerative joint diseases. Here, we demonstrate that cartilage-targeting fluorophores (CARFs) exhibit a remarkable cartilage-specific affinity and offer advanced imaging capabilities in the near-infrared II (NIR-II) window, characterized by minimal tissue scattering and negligible autofluorescence. CARFs show little to no toxicity, both in vitro (up to 100 μM) and in vivo (3 μmol/kg via intravenous injection), suggesting clinical potential. Furthermore, CARFs in the NIR-II window enable the precise visualization of cartilage lining, serving as a reliable diagnostic indicator for the early detection of arthritis in preclinical mouse models. CARFs are NIR fluorescence-emitting targeted contrast agents for prognostic imaging of joint tissue, with the potential to revolutionize applications in tissue engineering, joint surgery, and drug development for inflammatory diseases.

Indexed as

CartilageFluorophoresNIR-IIOptical imagingRheumatoid arthritis

Identifiers

PMID41306411
PMCPMC12646514

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.