Evidence map›Paper›PMID 41306346›Full record

ArticleCurrent opinion in biomedical engineering2025

Fuel, form, and memory: The motility-driven journey of cancer cells.

Carolina Trenado-Yuste, Celeste M Nelson

Abstract read
In one paragraph

Article in Current opinion in biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Carolina Trenado-YusteDepartment of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544.
Celeste M NelsonDepartment of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544.

Funding

Mechanical Clocks During Fetal DevelopmentDP1HD111539 · NICHD · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2022 to 2025
$5.7M
Engineered Invasive Human Breast Tumors with Integrated Capillaries and LymphaticsU01CA214292 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI NELSON, CELESTE M, TIEN, JOE Y · 2017 to 2021
$3.2M
Interplay between mechanical forces and retinoic acid in lung developmentR01HL164861 · NHLBI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2022 to 2025
$2.2M
Biophysical and Biochemical Effects of the ECM on Breast Epithelial CellsR01CA187692 · NCI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M, RADISKY, DEREK C · 2015 to 2019
$2.1M
Mechanical Forces and the Regulation of Airway Progenitor CellsR01HD099030 · NICHD · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2019 to 2023
$1.7M
Uncovering the mesenchyme-specific roles of planar cell polarity in lung developmentR01HL166311 · NHLBI · PRINCETON UNIVERSITY · PI Danelle N Devenport, Celeste M Nelson · 2025 to 2026
$1.2M
NCI NIH HHS R01 CA187692NCI NIH HHS U01 CA214292NHLBI NIH HHS R01 HL164861NHLBI NIH HHS R01 HL166311NICHD NIH HHS DP1 HD111539NICHD NIH HHS R01 HD099030
6 · The paper itself

Abstract

Tumor progression is a complex, multi-stage process that involves tumor formation, cancer cell invasion, and metastasis and colonization of distant sites. Each stage is driven in part by cell motility and interactions between cancer cells and their surrounding microenvironment. In this review, we describe how cell motility contributes to each stage of cancer progression, with a focus on cell metabolism, nuclear mechanics, and mechanical memory. Throughout, we highlight the mechanisms used by cancer cells to move and adapt during the metastatic cascade. Understanding how cancer cells migrate can provide valuable insights into novel approaches to disrupt metastasis and improve outcomes of cancer treatments.

Indexed as

Energy metabolismmorphogenesistissue morphodynamics

Identifiers

PMID41306346
PMCPMC12646604

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.