Evidence map›Paper›PMID 41306327›Full record

ArticleHemaSphere2025

Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia.

Haley Newman, Derek Wong, Jinhua Wu, Jeffrey Schubert, Netta Golenberg, Natali Naveh, Maha Patel, Feng Xu, Sarah Charles, Jiani Chen and 19 more

Abstract read
In one paragraph

Article in HemaSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Haley NewmanDivision of Oncology and Center for Childhood Cancer Research Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Derek WongDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Jinhua WuDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Jeffrey SchubertDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Netta GolenbergDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Natali NavehDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Maha PatelDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Feng XuDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Sarah CharlesDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Jiani ChenDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Elizabeth H DenenbergDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Elizabeth A FanningDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Daniel GalloDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Tammy LukeDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Morgan ThomasDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Kajia CaoDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Ada J S ChanDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Munashe HollomanDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Zhiqian FanDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Weixuan FuDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Stephen P HungerDivision of Oncology and Center for Childhood Cancer Research Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Suzanne P MacFarlandDivision of Oncology and Center for Childhood Cancer Research Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Kathrin M BerntDivision of Oncology and Center for Childhood Cancer Research Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Lea F SurreyDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Minjie LuoDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Gerald B WertheimDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Marilyn M LiDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Sarah K TasianDivision of Oncology and Center for Childhood Cancer Research Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.
Yiming ZhongDivision of Genomic Diagnostics Children's Hospital of Philadelphia Philadelphia Pennsylvania United States.ORCID https://orcid.org/0000-0002-6596-6952

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancements in the rapidity, cost efficacy, and sensitivity of next-generation sequencing (NGS) have facilitated molecular risk stratification and precision medicine-based treatment for pediatric leukemia. The benefit of uniform cytomolecular analyses for clinical trial risk assignment is clear. However, the clinical impact of comprehensive NGS for pediatric leukemias at an institutional level is not well described. We report the genomic spectrum of one of the largest cohorts of pediatric and adolescent/young adult (AYA) acute leukemias examined to date (

Identifiers

PMID41306327
PMCPMC12645502

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.