Evidence map›Paper›PMID 41306316›Full record

ArticleEJHaem2025

Donor-Derived T-Cell Redirection With Epcoritamab Achieving Complete Response After Early Post-Allo-HSCT Relapse of DLBCL.

Yoshikazu Ikoma, Yuto Kaneda, Ryoma Shimazu, Daisuke Okamoto, Takuro Matsumoto, Nobuhiko Nakamura, Hiroshi Nakamura, Nobuhiro Kanemura, Hideko Goto, Naoki Katsumura and 1 more

Abstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yoshikazu IkomaDepartment of Hematology and Infectious Disease Gifu University Hospital Gifu Japan.ORCID https://orcid.org/0009-0008-4780-9137
Yuto KanedaDepartment of Hematology and Infectious Disease Gifu University Hospital Gifu Japan.
Ryoma ShimazuDepartment of Hematology and Infectious Disease Gifu University Hospital Gifu Japan.
Daisuke OkamotoDepartment of Hematology and Infectious Disease Gifu University Hospital Gifu Japan.
Takuro MatsumotoDepartment of Hematology and Infectious Disease Gifu University Hospital Gifu Japan.
Nobuhiko NakamuraDepartment of Hematology and Infectious Disease Gifu University Hospital Gifu Japan.ORCID https://orcid.org/0000-0003-1682-7777
Hiroshi NakamuraDepartment of Hematology and Infectious Disease Gifu University Hospital Gifu Japan.
Nobuhiro KanemuraDepartment of Hematology and Infectious Disease Gifu University Hospital Gifu Japan.
Hideko GotoDepartment of Hematology Chuno Kosei Hospital Gifu Japan.
Naoki KatsumuraDepartment of Gastroenterology Chuno Kosei Hospital Gifu Japan.
Masahito ShimizuDepartment of Hematology and Infectious Disease Gifu University Hospital Gifu Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Epcoritamab, a bispecific CD3×CD20 antibody, offers a promising treatment for relapsed diffuse large B-cell lymphoma (DLBCL). Its efficacy and safety after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain unclear. Case Report: In a 64-year-old man with relapsed DLBCL, epcoritamab showed limited efficacy, achieving stable disease prior to allo-HSCT; nevertheless, re-administration after donor T-cell engraftment resulted in a complete response without severe graft-versus-host disease or cytokine release syndrome. Conclusions: This observation suggests that donor-derived T-cell redirection with epcoritamab may enhance antitumor efficacy while maintaining safety in the post-transplant setting, supporting its potential as a salvage therapy for relapsed DLBCL post-allo-HSCT.

Indexed as

bispecific antibodiesdiffuse large B‐cell lymphomagraft‐versus‐host diseasehaematopoietic stem cell transplantationimmunotherapy

Identifiers

PMID41306316
PMCPMC12644927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.