Evidence map›Paper›PMID 41306310›Full record

ArticleEnvironment & health (Washington, D.C.)2025

MeP Induces Metabolic Disorder and Liver Damage at Human-Relevant Exposure Levels: Role of the Gut Microbiota.

Henglin Zhang, Yanan Zhao, Haitao Tu, Yuxian Liu, Yiling Lin, Yanpeng Cai, Liang Chi, Tao Zhang, Bingling Dai, Jingchuan Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Henglin ZhangGuangdong Basic Research Center of Excellence for Ecological Security and Green Development, Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou 510006, China.
Yanan ZhaoGuangdong Basic Research Center of Excellence for Ecological Security and Green Development, Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou 510006, China.
Haitao TuDivision of Nephrology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Yuxian LiuKey Laboratory of Ministry of Education for Water Quality Security and Protection in Pearl River Delta, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China.
Yiling LinGuangdong Basic Research Center of Excellence for Ecological Security and Green Development, Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou 510006, China.
Yanpeng CaiGuangdong Basic Research Center of Excellence for Ecological Security and Green Development, Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou 510006, China.
Liang ChiMOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing 210061, China.
Tao ZhangSchool of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China.ORCID https://orcid.org/0000-0002-4424-0423
Bingling DaiSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Jingchuan XueGuangdong Basic Research Center of Excellence for Ecological Security and Green Development, Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou 510006, China.ORCID https://orcid.org/0000-0003-1069-8919

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methylparaben (MeP) is a widely used preservative found in many consumer products that leads to extensive human exposure. Despite some health concerns, our understanding of MeP's effects on metabolic homeostasis remains limited. This study investigated the effects of MeP on body growth, metabolic homeostasis, and liver health in male C57BL/6J mice. We found that at human-relevant exposure levels, MeP impaired body weight gain, elevated serum tumor necrosis factor-α (TNF-α), disrupted metabolic parameters, and caused liver injury. In addition, these toxic effects were associated with altered gut microbiota composition. Depleting gut bacteria with antibiotics abolished MeP-induced adverse effects on weight, inflammation, and metabolism, although liver damage persisted. This study provides important insights into MeP toxicity in metabolic homeostasis and highlights the key regulatory roles of the gut microbiota.

Indexed as

growth impairgut microbiotaliver injurymetabolic disordermethyl paraben

Identifiers

PMID41306310
PMCPMC12645305

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.