Evidence map›Paper›PMID 41306299›Full record

ArticleEnvironment & health (Washington, D.C.)2025

Enantioselective Modulation of Inflammatory Response through MAPK Pathway by Wavelike Chiral Nanoparticles.

Yijin Tian, Jinghua Hao, Chao Lin, Deming Han, Nali Zhu, Zhigang Li, Lixia Zhao, Lingxiangyu Li, Yawei Wang, Guibin Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yijin TianSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Jinghua HaoSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Chao LinSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Deming HanSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0001-7472-5563
Nali ZhuSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0002-3145-5695
Zhigang LiSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0009-0009-4051-6312
Lixia ZhaoSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0002-2068-4732
Lingxiangyu LiSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0002-2611-380X
Yawei WangSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0002-6115-4076
Guibin JiangSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0002-6335-3917

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious inflammation remains a major global health issue, so novel strategies to alleviate inflammatory responses are urgently required. Cinnabar (α-HgS) used in traditional Chinese medicine shows protective effects against inflammation, but low anti-inflammatory efficacies ascribed to poor solubility and bioavailability have hindered extensive applications of cinnabar. Nanoscale chirality provides chances to improve efficacies through enantiomer-dependent interactions between cells and chiral cinnabar nanoparticles (HgSNPs). Herein HgSNPs with intrinsically wavelike chirality were prepared through a one-pot seedless method, exhibiting efficacious alleviation of inflammation

Indexed as

Chiral cinnabar nanoparticlesEnantiomer-dependent uptakeInfectious inflammationMacrophagesMitogen-activated protein kinase pathway

Identifiers

PMID41306299
PMCPMC12645301

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.