ArticleFrontiers in cell and developmental biology2025
Proximity-based proteomics (BioID) uncovers the Rho GTPase interactome in kidney podocytes.
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Rho/ROCK Signaling Pathway in Kidney Diseases: Mechanisms and Therapeutic Perspectives.Biomedicines · 2026Review
- Emerging genetic mechanisms of glomerular proteinuria: a podocyte-centered multi-layer network perspective.Frontiers in genetics · 2026Review
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Authors and funding
13 authors.
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Abstract
Introduction: Podocyte injury causes proteinuria. Rho GTPases play critical roles in regulating the podocyte cytoskeleton, and their alteration leads to foot process effacement. Yet, their signaling networks remain poorly understood. Methodology: To address this, we mapped the interactomes of RhoA, Rac1, and Cdc42 in human podocytes using proximity-dependent biotin identification (BioID) labeling. Results and discussion: Our BioID analysis detected a total of 1927 interactions with AvgP ≥ 0.95. Approximately 50% of the interactions are unique to podocytes compared to interactions in HEK293 and HeLa cells, with enrichment in pathways related to cell adhesion and shape organization.
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