SynthesisFrontiers in oral health2025
Risk factors associated with the failure of secondary alveolar bone grafting with autologous iliac crest bone in patients with alveolar cleft defects: a systematic review.
Synthesis in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Current Animal Models of Cleft Lip and/or Palate: A Narrative Review.Biomedicines · 2026Review
- Graft materials and regenerative strategies in secondary alveolar bone grafting: A scoping review of randomized clinical trials.Journal of oral biology and craniofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to perform a systematic review of the risk factors associated with secondary alveolar bone grafting (SABG) failure in patients with cleft alveolus. Methods: A comprehensive search was conducted across PubMed, Scopus, Embase, and Web of Science databases from their inception to 24 February 2025, to identify relevant studies. The search keywords included "alveolar cleft" combined with either "survival" or "failure." Studies that investigated risk factors for the failure of SABG using autologous iliac crest bone were included in this review. Relevant data, including odds ratios, hazard ratios, or comparisons of variables between patients with and without SABG failure, were recorded and analyzed. Results: A total of nine studies, encompassing 1,855 grafts, were included. The most commonly used definition of SABG failure was Bergland grade 3 or 4. Reported failure rates varied significantly across studies, ranging from 1.0% to 45.1%. The primary risk factors for SABG failure included increased age at SABG (reported in four studies), poor oral hygiene (two studies), and the presence of an erupted lateral or canine tooth (three studies). Additionally, non-Caucasian ethnicity, international adoptee, large cleft size, a history of cleft lip/palate revision or oronasal fistula, nasoalveolar molding, and premaxillary osteotomy were also associated with a higher risk of SABG failure. No significant association was found between SABG failure and sex, alveolar cleft type (bilateral or unilateral), preoperative expansion, or preoperative orthodontics. Conclusions: The definition of SABG failure varied across studies, with Bergland grade 3 or 4 being the most commonly used criteria. The primary risk factors for SABG failure included increased age, poor oral hygiene, and the presence of an erupted lateral or canine tooth. Surgeons should be aware of these risk factors to optimize surgical strategies and guide patients effectively.
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