ArticleCureus2025
Efficacy of a Single-Loading Dose of Magnesium Sulphate in Preventing Convulsions in Women With Eclampsia: A Quasi-experimental Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Eclampsia remains a major contributor to maternal morbidity and mortality in low-resource settings. Magnesium sulphate is the anticonvulsant of choice; however, prolonged maintenance regimens can be challenging to implement. This study aimed to evaluate the efficacy of a single-loading dose of magnesium sulphate in preventing recurrent convulsions among women presenting with eclampsia. This analytical quasi-experimental study was conducted in the Obstetrics and Gynecology units of Civil Hospital, Karachi, from September 8, 2021, to March 7, 2022. A total of 113 women aged 18-40 years, with singleton pregnancies between 37 and 41 weeks of gestation and diagnosed with eclampsia, were enrolled through non-probability consecutive sampling. Each participant received a single IV dose of magnesium sulphate (4 g IV over 8-10 minutes followed by 4 g intramuscular (IM)). No maintenance dose was given. Efficacy, defined as the absence of recurrent convulsions within 24 hours, was recorded. Data were analyzed using SPSS version 26.0, with chi-square tests applied to assess associations (
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