Evidence map›Paper›PMID 41306151›Full record

ArticleCureus2025

Corneal Endothelial Changes in Primary Glaucoma: A Qualitative and Quantitative Evaluation by Disease Subtype and Antiglaucoma Medication Burden.

Pravin Dhoriyanee, Seema Meena, Kavita R Bhatnagar, Nikhil Agrawal, Manjari Tandon, Suwarna Suman, Kirti Jaisingh, Jyoti Shakrawal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pravin DhoriyaneeOphthalmology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.
Seema MeenaOphthalmology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.
Kavita R BhatnagarOphthalmology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.
Nikhil AgrawalOphthalmology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.
Manjari TandonOphthalmology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.
Suwarna SumanOphthalmology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.
Kirti JaisinghOphthalmology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.
Jyoti ShakrawalOphthalmology, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Corneal endothelial cells (CECs) are critical for maintaining corneal clarity but have limited regenerative potential. Glaucoma and its treatment may compromise endothelial integrity. This study evaluated corneal endothelial changes in primary glaucoma, stratified by disease subtype and antiglaucoma medication (AGM) burden. Methods This cross-sectional study included 60 eyes of 34 patients with primary glaucoma and 60 eyes of 30 age- and sex-matched controls. Corneal endothelial parameters were assessed with a Tomey EM-4000 specular microscope. Patients were categorized as primary open-angle glaucoma (POAG) or primary angle-closure glaucoma (PACG) and further subgrouped by the number of topical AGMs. Results Glaucoma patients had lower endothelial cell density (ECD) (2325.86 ± 378.6 vs 2527.08 ± 197.05 cells/mm²;

Indexed as

antiglaucoma medicationscorneal endotheliumendothelial cell densityglaucomaprimary angle closure glaucomaprimary open angle glaucoma

Identifiers

PMID41306151
PMCPMC12645418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.