Evidence map›Paper›PMID 41306047›Full record

ArticleACS applied bio materials2025

Potential of Nitric Oxide and Bacteriophages as Combined Antibacterial Agents to Counter Drug-Resistant Infections.

Sarah N Wilson, Vijay Singh Gondil, Elizabeth J Brisbois, Hitesh Handa

Abstract read
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah N WilsonSchool of Chemical, Materials, and Biological Engineering, University of Georgia, Athens, Georgia 30605, United States.
Vijay Singh GondilSchool of Chemical, Materials, and Biological Engineering, University of Georgia, Athens, Georgia 30605, United States.
Elizabeth J BrisboisSchool of Chemical, Materials, and Biological Engineering, University of Georgia, Athens, Georgia 30605, United States.ORCID 0000-0002-9283-5448
Hitesh HandaSchool of Chemical, Materials, and Biological Engineering, University of Georgia, Athens, Georgia 30605, United States.ORCID 0000-0002-9369-7374

Funding

Nitric Oxide Functionalized Antibiotics to Combat Infections and Thrombosis for Extracorporeal Life SupportR01HL172496 · NHLBI · UNIVERSITY OF GEORGIA · PI Elizabeth Joy Brisbois, Hitesh Handa · 2024 to 2026
$1.5M
NHLBI NIH HHS R01 HL172496
6 · The paper itself

Abstract

The ongoing threat of antimicrobial-resistant (AMR) bacteria and the growing population of AMR bacteria have inspired research into alternative antimicrobial agents. Previous studies have shown clinically relevant bactericidal effects of the molecule nitric oxide (NO). Not only has extensive research proven its antimicrobial effect, but bacteria have also been shown to be less likely to become resistant to NO. Numerous studies have also demonstrated that NO is compatible with commercially available antibiotic drugs, enhancing antimicrobial effects. However, these drugs are not always readily available or easily manufactured. This study proposes combining NO with naturally sourced antibacterial agents, namely bacteriophages. This combination of NO with bacteriophages in solution demonstrated an 82 ± 1.7% killing efficiency against its target pathogen,

Indexed as

Anti-Bacterial AgentsBacteriophagesBiocompatible MaterialsEscherichia coliMethicillin-Resistant Staphylococcus aureusNitric OxideDrug Resistance, BacterialHumansMaterials TestingMicrobial Sensitivity TestsAnti-Bacterial AgentsBiocompatible MaterialsNitric Oxideantimicrobial resistancebacteriophagebiomedicalcombination therapynitric oxide

Identifiers

PMID41306047
PMCPMC12709577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.