Evidence map›Paper›PMID 41305856›Full record

ArticleJournal of dental research2026

Stage-Specific Proteomic Profiles in Dental Caries.

C M P Vidal, O Rysavy, S Kulanthaivel, E Zeng, B Cavalcanti, M R Carrilho, E M S Araujo, S R B Cunha, D Drake, X J Xie and 1 more

Abstract read
In one paragraph

Article in Journal of dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

C M P VidalDepartment of Operative Dentistry, The University of Iowa, College of Dentistry, Iowa City, IA, USA.ORCID 0000-0003-4345-8487
O RysavyDivision of Biostatistics and Computational Biology, The University of Iowa, College of Dentistry, Iowa City, IA, USA.
S KulanthaivelDepartment of Operative Dentistry, The University of Iowa, College of Dentistry, Iowa City, IA, USA.
E ZengDivision of Biostatistics and Computational Biology, The University of Iowa, College of Dentistry, Iowa City, IA, USA.
B CavalcantiDepartment of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-0455-4823
M R CarrilhoCollege of Dental Medicine - Illinois, Midwestern University, Downers Grove, IL, USA.ORCID 0000-0002-7171-6108
E M S AraujoDepartment of Operative Dentistry, The University of Iowa, College of Dentistry, Iowa City, IA, USA.
S R B CunhaDepartment of Operative Dentistry, The University of Iowa, College of Dentistry, Iowa City, IA, USA.
D DrakeIowa Institute of Oral Health Research, The University of Iowa, College of Dentistry, Iowa City, IA, USA.
X J XieIowa Institute of Oral Health Research, The University of Iowa, College of Dentistry, Iowa City, IA, USA.
J BanasIowa Institute of Oral Health Research, The University of Iowa, College of Dentistry, Iowa City, IA, USA.

Funding

Modulation of MMPs gene expression and activity by the microbiome in cariesK08DE029490 · NIDCR · UNIVERSITY OF IOWA · PI DE MATTOS PIMENTA VIDAL, CRISTINA · 2021 to 2025
$801k
NIDCR NIH HHS K08 DE029490
6 · The paper itself

Abstract

This study investigated the proteomic landscape of sound and carious coronal dentin to uncover the molecular signatures of host response, including tissue degradation, inflammation, and repair, across progressive stages of caries lesions. Dentin from deidentified human molars, grouped into 6 clusters of 3 teeth each, was pulverized to obtain ~1 g of tissue per cluster (

Indexed as

Dental CariesDentinProteomeProteomicsChromatography, LiquidHumansTandem Mass SpectrometryProteomedentininflammationliquid chromatography-mass spectrometryproteins, pulpitisproteomics

Identifiers

PMID41305856
PMCPMC12751097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.