ArticleMedicine2025
A study revealed the impact of gut microbiota on acne vulgaris: Evidence based on Mendelian randomization.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gut and skin dysbiosis in acne vulgaris: a comparative microbiome analysis.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cumulative evidence has demonstrated an association between gut microbiota and acne vulgaris. However, previous studies have yielded mixed results, and despite extensive investigations, the causal relationship between them remains unclear. The genome-wide association studies summary data of 196 gut microbiota and acne vulgaris was obtained from the most extensive available genome-wide association studies database. A 2-sample Mendelian randomization (MR) study, which utilizes genetic variants as instrumental variables in 2 independent datasets to assess causal relationships between an exposure and an outcome, was used to test the causal relationship between the gut microbiota and acne vulgaris. The MR analysis was primarily performed with the inverse variance weighted method, and MR-Egger, Cochran Q test and Mendelian randomization pleiotropic residuals and outliers were performed as sensitivity analyses. The inverse variance weighted analysis revealed that the risk of acne formation was correlated with a total of 14 gut microbiota taxa that predicted the composition of intestinal flora. Among them, class Coriobacteriia (odds ratio [OR] = 0.588, 95% confidence interval [CI]: 0.357-0.966, P = .036), class Erysipelotrichia (OR = 0.559, 95% CI: 0.357-0.966, P = .036), family Coriobacteriaceae (OR = 0.599, 95% CI: 0.357-0.966, P = .036), family Erysipelotrichaceae (OR = 0.559, 95% CI: 0.325-0.963, P = .036), genus Candidatus Soleaferrea (OR = 0.576, 95% CI: 0.355-0.934, P = .025), genus Fusicatenibacter (OR = 0.533, 95% CI: 0.306-0.927, P = .026), genus Lactobacillus (OR = 0.658, 95% CI: 0.450-0.963, P = .031), order Erysipelotrichales (OR = 0.559, 95% CI: 0.325-0.963, P = .036) abundance was negatively correlated with acne vulgaris incidence. Family Bacteroidaceae (OR = 2.579, 95% CI: 1.237-5.378, P = .011), family Family XIII (OR = 1.456, 95% CI: 1.173-4.288, P = .015), genus Allisonella (OR = 1.385, 95% CI: 1.003-4.288, P = .015), genus Bacteroides (OR = 2.444, 95% CI: 1.053-5.671, P = .037), genus Coprococcus3 (OR = 2.122, 95% CI: 1.095-4.111, P = .026), genus Romboutsia (OR = 1.677, 95% CI: 1.064-2.645, P = .026) abundance had a positive correlation with acne vulgaris development. The reliability and robustness of the findings were confirmed using a variety of sensitivity analyses, including MR-Egger regression, Cochran Q test, and Mendelian randomization pleiotropic residuals and outliers, which revealed no indication of horizontal pleiotropy or significant heterogeneity among single nucleotide polymorphisms. The MR study has validated the potential causal relationship between gut microbiota and acne vulgaris, providing some insights into potential therapeutic targets and interventions for this dermatological concern. Nevertheless, further investigation is warranted to understand the underlying mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.