Evidence map›Paper›PMID 41305801›Full record

ArticleMedicine2025

Comprehensive management of immune-related hemolytic anemia in a patient with acute cholangitis: A case report.

Jun Chen, Xian-Feng Wang, Jin Yu, Sheng Xu, Feng Zheng, Zhong-Kai Ni

Abstract readCase Reports
In one paragraph

Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun ChenDepartment of Critical Care Medicine, Hangzhou Lin'an Traditional Chinese Medicine Hospital, Hangzhou, Zhejiang Province, China.
Xian-Feng WangDepartment of General Surgery, Hangzhou Lin'an Traditional Chinese Medicine Hospital, Hangzhou, Zhejiang Province, China.
Jin YuDepartment of Clinical Laboratory, Hangzhou Lin'an Traditional Chinese Medicine Hospital, Hangzhou, Zhejiang Province, China.
Sheng XuDepartment of Critical Care Medicine, Hangzhou Lin'an Traditional Chinese Medicine Hospital, Hangzhou, Zhejiang Province, China.
Feng ZhengDepartment of General Surgery, Hangzhou Lin'an Traditional Chinese Medicine Hospital, Hangzhou, Zhejiang Province, China.
Zhong-Kai NiDepartment of General Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, China.ORCID 0009-0008-5530-9802

Funding

Zhejiang Traditional Medicine and Technology Program, China 2024ZL842
6 · The paper itself

Abstract

abstractrationaleImmune-associated hemolytic anemia is an uncommon and potentially life-threatening complication in patients with choledocholithiasis and acute cholangitis. Its occurrence during the perioperative period remains rarely reported. PATIENT CONCERNS: A 69-year-old woman presented with right upper abdominal pain and was diagnosed with choledocholithiasis and acute cholangitis. During hospitalization, she developed sudden confusion and shock, with her hemoglobin rapidly declining to 26 g/L. DIAGNOSES: The patient was diagnosed with acute cholangitis and immune-related hemolytic anemia based on clinical manifestations and a positive direct antihuman globulin (Coombs) test.

interventionsThe patient received high-dose glucocorticoid therapy combined with red blood cell transfusion, followed by endoscopic retrograde cholangiopancreatography with endoscopic sphincterotomy and nasobiliary drainage to relieve biliary obstruction, and subsequent laparoscopic cholecystectomy. OUTCOMES: After timely diagnosis and comprehensive management, the patient's hemoglobin stabilized, hemolysis resolved, and she recovered without postoperative complications. LESSONS: This case provides 3 important lessons for clinical practice: The need for prompt recognition and management of unexpected perioperative complications and flexible adjustment of clinical thinking. A systematic approach for handling sudden and life-threatening hemoglobin decline. Appropriate timing and optimal surgical strategy selection for delayed definitive surgery after stabilization.

Indexed as

Anemia, HemolyticAnemia, Hemolytic, AutoimmuneCholangitisCholedocholithiasisAcute DiseaseAgedCholangiopancreatography, Endoscopic RetrogradeCholecystectomy, LaparoscopicErythrocyte TransfusionFemaleGlucocorticoidsHumansGlucocorticoidsacute cholangitischoledocholithiasisendoscopic retrograde cholangiopancreatographyimmune-associated hemolytic anemiaperioperative treatment

Identifiers

PMID41305801
PMCPMC12643782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.