SynthesisMedicine2025
Exophiala infection: A systematic review.
Synthesis in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- First case report of onychomycosis caused byMedical mycology case reports · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGiven the limited understanding of this rare fungal disease, this study aimed to conduct a systematic review of patients with Exophiala infections.
methodsA systematic retrospective analysis was performed, including 248 articles involving 298 patients, retrieved from PubMed and China National Knowledge Infrastructure. Statistical analyses were conducted using the Chi-square test and binary logistic regression by SPSS 27.0.
resultsA total of 19 Exophiala species were identified, with E dermatitidis, E jeanselmei, and E spinifera being the most prevalent. Common infection sites included subcutaneous tissue, lung, and skin, with distinct site predilections among different species. Central nervous system (CNS) infection was the only independent risk factor for mortality (P < .001, OR = 35.432). For E dermatitidis, the risk of infecting the skin (P < .001, OR = 0.075, 95% CI = 0.017-0.335) and subcutaneous tissue (P < .001, OR = 0.035) was significantly lower, while the risk of infecting the lungs (P < .001, OR = 44.850), CNS (P = .002, OR = 4.523), and blood (P < .001, OR = 12.498) was significantly higher. E jeanselmei showed a higher risk of subcutaneous tissue infection (P < .001, OR = 4.221) but lower risks of lung (P = .003, OR = 0.045) and CNS (P = .039, OR = 0.118) infections. E spinifera had a higher risk of infecting both subcutaneous tissue (P < .001, OR = 6.598) and skin (P = .006, OR = 3.778).
conclusionsExophiala species exhibit distinct predilections for infection sites, and CNS infection is a critical risk factor for mortality. These findings may inform clinical diagnosis and management of Exophiala infections.
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