Observational studyMedicine2025
Depression and cancer-related fatigue in elderly colorectal cancer patients: A cross-sectional study with focus on the mediating role of chemotherapy-induced peripheral neuropathy and the moderating role of perceived social support.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Chemotherapy-induced peripheral neuropathy and social interaction anxiety in breast cancer patients: a cross-sectional study.BMC women's health · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examines whether chemotherapy-induced peripheral neuropathy (CIPN) mediates the relationship between depression and cancer-related fatigue (CRF) and further investigates the moderating role of perceived social support (PSS) in this relationship among Chinese older adults with colorectal cancer (CRC). A total of 290 elderly Chinese patients with CRC undergoing chemotherapy were recruited. Structured questionnaires were administered to assess levels of depression, symptoms of CIPN, CRF, and PSS. Moderated mediation models were tested using the PROCESS macro (Models 4 and 8) in SPSS, controlling for relevant demographic and clinical covariates, to examine the hypothesized path relationships and interaction effects. After controlling for relevant covariates, CIPN was found to partially mediate the relationship between depression and CRF (indirect effect = 0.231), accounting for 38.44% of the total effect. Moreover, PSS significantly moderated the associations between depression with both CIPN (β = 0.101, P < .05) and CRF (β = 0.018, P < .05), such that higher levels of PSS strengthened these relationships. CIPN may be a potential pathway reflecting how emotional disturbances, particularly depression, are associated with CRF in elderly patients with CRC. The subjective experience of CIPN appears to be closely related to depressive symptoms. Contrary to the classical stress-buffering hypothesis, PSS did not exhibit a protective effect; rather, in certain cultural contexts, it may be linked to the physiological manifestations of negative emotions. These findings underscore the need for culturally sensitive and context-specific approaches to emotional intervention and social support in symptom management to optimize individualized care strategies for elderly CRC patients.
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