Evidence map›Paper›PMID 41305741›Full record

Observational studyMedicine2025

Thrombotic complications in critically ill patients with coronavirus infections: A comparative study of MERS and COVID-19.

Mosaad Almegren, Turki Alshuaibi, Amal M Alhusayni, Abdulrahman Alraizah, Rayan Qutob, Bader Al Rawahi, Eysa Alsolamy, Fatima Sharif

Abstract readComparative StudyObservational Study
In one paragraph

Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mosaad AlmegrenImam Mohammad ibn Saud Islamic University, Riyadh, Saudi Arabia.
Turki AlshuaibiKing Fahad Hospital, Jeddah, Saudi Arabia.
Amal M AlhusayniKing Fahad Hospital, Jeddah, Saudi Arabia.
Abdulrahman AlraizahKing Abdulaziz Medical City, Riyadh, Saudi Arabia.
Rayan QutobImam Mohammad ibn Saud Islamic University, Riyadh, Saudi Arabia.
Bader Al RawahiSultan Qaboos University Hospital, Muscat, Oman.
Eysa AlsolamyImam Mohammad ibn Saud Islamic University, Riyadh, Saudi Arabia.
Fatima SharifMedi Test Lab and Diagnostic Center, Islamabad, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronaviruses include coronavirus disease 2019 (COVID-19) and Middle East respiratory syndrome (MERS). These viruses cause respiratory infections in humans and share several overlapping structural, pathological, and genetic features. This study compared arterial and venous thrombotic events in critically ill patients with COVID-19 and MERS. This study was conducted in the intensive care units of 2 hospitals in Saudi Arabia. Polymerase chain reaction-positive patients who were diagnosed with COVID-19 between February and July 2020 and polymerase chain reaction-positive patients with MERS from March to May 2014 were included. The data were analyzed via SAS version 9.4 (SAS Institute, Cary, NC). This study included 294 patients, 234 (79.6%) of whom had COVID-19, and 60 (20.4%) had MERS. Overall, the rate of composite thrombotic events was 44 (14.97%) in both groups, comprising 25 patients with venous thromboembolism (23 patients with COVID-19 and 2 in the MERS group) and 19 with arterial thrombotic episodes (14 patients with COVID-19 and 5 in the MERS group). Bronchial asthma was significantly associated with thrombosis (P = .02). Enoxaparin was the most frequently prescribed thromboprophylaxis 189 (64.5%). There was no significant difference in venous thromboembolism (P = .10), bleeding complications (P = .53), or mortality (P = .08) between the COVID-19 and MERS patients. We found a similar rate of composite thrombotic events in critically ill patients with COVID-19 and MERS. While the thrombotic tendency of patients with COVID-19 was previously known, we uniquely identified the role of MERS in both arterial and venous thrombosis.

Indexed as

COVID-19ThrombosisAdultAgedAnticoagulantsCritical IllnessFemaleHumansIntensive Care UnitsMaleMiddle AgedMiddle East Respiratory Syndrome CoronavirusSARS-CoV-2Saudi ArabiaAnticoagulantsCOVID-19critical careMERS-CoVthrombosis

Identifiers

PMID41305741
PMCPMC12643631

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.