Observational studyMedicine2025
Preimplantation genetic testing for aneuploidy in young women with recurrent spontaneous abortion.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
This study aimed to investigate whether preimplantation genetic testing for aneuploidy (PGT-A) improves pregnancy outcomes in in vitro fertilization-embryo transfer (IVF-ET) cycles in patients with recurrent spontaneous abortion (RSA). A total of 216 young patients with RSA (aged <38 years) who underwent IVF were included in this study. Of these, 114 patients opted for PGT-A, comprising 64 patients with a history of embryonic chromosome abnormality (ECA) (Group A) and 50 patients without ECA (Group B). The remaining 102 patients who did not undergo PGT-A served as the Control group, including 51 patients with a history of ECA (Control A) and 51 patients without ECA (Control B). Clinical outcomes were compared between the groups. The live birth rate in Group A was significantly higher compared to Control A (P <.05), whereas no significant difference was observed between groups B and Control B (P >.05). PGT-A significantly improved clinical outcomes in RSA patients with a history of ECA, but did not show a similar benefit in those without ECA. However, owing to the retrospective nature of the analysis and potential for unmeasured confounding factors, the value of PGT-A in women with RSA warrants further investigation.
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