Evidence map›Paper›PMID 41305666›Full record

ArticleNutrients2025

In Vitro Insights into the Antifungal, Prebiotic, and Cytotoxic Potential of Tomato Plant Waste.

Simona Marcu Spinu, Mihaela Dragoi Cudalbeanu, Carmen Laura Cimpeanu, Nikola Major, Elwira Sieniawska, Krzysztof Kamil Wojtanowski, Ionela Avram, Diana Pelinescu, Alina Ortan, Narcisa Elena Babeanu

Abstract read
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In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Simona Marcu SpinuFaculty of Land Reclamation and Environmental Engineering, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Boulevard, 011464 Bucharest, Romania.
Mihaela Dragoi CudalbeanuFaculty of Land Reclamation and Environmental Engineering, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Boulevard, 011464 Bucharest, Romania.
Carmen Laura CimpeanuFaculty of Land Reclamation and Environmental Engineering, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Boulevard, 011464 Bucharest, Romania.
Nikola MajorInstitute of Agriculture and Tourism, 52440 Poreč, Croatia.ORCID 0000-0002-4922-3681
Elwira SieniawskaDepartment of Natural Products Chemistry, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-4773-0329
Krzysztof Kamil WojtanowskiDepartment of Pharmacognosy with Medicinal Plants Garden, Medical University of Lublin, 20-093 Lublin, Poland.
Ionela AvramDepartment of Genetics, University of Bucharest, 1-3 Aleea Portocalelor, 060101 Bucharest, Romania.ORCID 0000-0002-9171-0846
Diana PelinescuDepartment of Genetics, University of Bucharest, 1-3 Aleea Portocalelor, 060101 Bucharest, Romania.
Alina OrtanFaculty of Land Reclamation and Environmental Engineering, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Boulevard, 011464 Bucharest, Romania.ORCID 0000-0003-0925-1677
Narcisa Elena BabeanuFaculty of Biotechnologies, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Boulevard, 011464 Bucharest, Romania.

Funding

This study was supported by a grant of the Romanian Ministry of Education and Research, CCCDI-UEFISCDI PN-IV-P7-7.1-PED-2024-2366, contract 123PED/2025 within PNCDI IV
6 · The paper itself

Abstract

BACKGROUND/

objectivesThis study aims to screen the extracts of tomato plant waste (aerial parts-mixture of leaves, stems, and bunches resulting from tomato crop maintenance, and axillary shoots-resulting from pruning practices) and evaluate their antifungal, prebiotic, and cytotoxic effects.

methodsA phytochemical profiling was performed to analyze volatile and semi-volatile compounds by GC-MS, functional groups by FTIR, soluble sugars by HPLC-RI, and glycoalkaloids by LC-MS/MS. Tomato plant waste extracts were further tested in vitro, and their biological effects were assessed with probiotic microorganisms (

resultsThe in vitro antimicrobial activity and prebiotic-like substrate assay proved the difference between extract effects against

conclusionsOverall, this research highlights tomato axillary shoots as a sustainable source of bioactive compounds, with potential applications in developing natural, plant-based prebiotic products that exhibit antifungal and antitumor activity. This research focuses on developing natural, plant-based prebiotic products with antifungal and cytotoxic effects.

Indexed as

Antifungal AgentsPlant ExtractsPrebioticsSolanum lycopersicumCandidaHEK293 CellsHeLa CellsHep G2 CellsHT29 CellsHumansMicrobial Sensitivity TestsPhytochemicalsAntifungal AgentsPhytochemicalsPlant ExtractsPrebioticsantifungal effectCandida speciescytotoxicity effectFTIRGC-MSglycoalkaloidshealth approachleaves wasteprebiotic effectsoluble sugars

Identifiers

PMID41305666
PMCPMC12655068

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.