Evidence map›Paper›PMID 41305653›Full record

ReviewNutrients2025

Nutritional Supplements for Muscle Hypertrophy: Mechanisms and Morphology-Focused Evidence.

Andreea Maria Mănescu, Simona Ștefania Hangu, Dan Cristian Mănescu

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andreea Maria MănescuFaculty of AgriFood and Environmental Economics, Bucharest University of Economic Studies, 010374 Bucharest, Romania.ORCID 0009-0006-0202-4542
Simona Ștefania HanguFaculty of AgriFood and Environmental Economics, Bucharest University of Economic Studies, 010374 Bucharest, Romania.
Dan Cristian MănescuFaculty of AgriFood and Environmental Economics, Bucharest University of Economic Studies, 010374 Bucharest, Romania.ORCID 0009-0004-9406-8555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nutritional supplementation is widely used in resistance training, yet assessment of "hypertrophy" is often confounded by body-composition surrogates. This narrative review, anchored in mechanistic plausibility, integrates trials reporting morphology-direct outcomes (ultrasound/MRI). Across 46 eligible trials, protein/essential amino acids (EAA) showed consistent benefits when daily intake was <1.6 g·kg

Indexed as

Dietary SupplementsMuscle, SkeletalResistance TrainingAmino Acids, EssentialCreatineHumansHypertrophyValeratesAmino Acids, Essentialbeta-hydroxyisovaleric acidCreatineValeratescitrullinecollagen peptidescreatine monohydrateHMBleucine thresholdMRImuscle protein synthesisomega-3 fatty acidsresistance trainingskeletal muscleultrasound

Identifiers

PMID41305653
PMCPMC12655760

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.