Evidence map›Paper›PMID 41305556›Full record

ReviewNutrients2025

The Role of Diet in Women of Childbearing Age: Current Evidence Supporting Nutritional Recommendations.

Andrea Maugeri, Martina Barchitta, Giuliana Favara, Roberta Magnano San Lio, Claudia Ojeda-Granados, Elena Alonzo, Daniele Bellavia, Marialaura Bonaccio, Annalisa Di Nucci, Chiara Donfrancesco and 11 more

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Andrea MaugeriDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.ORCID 0000-0003-2655-8574
Martina BarchittaDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.ORCID 0000-0002-0905-5003
Giuliana FavaraDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.
Roberta Magnano San LioDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.ORCID 0000-0003-2023-2135
Claudia Ojeda-GranadosDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.ORCID 0000-0001-9734-558X
Elena AlonzoServizio Igiene degli Alimenti e Nutrizione (SIAN), Azienda Sanitaria Provinciale, 95100 Catania, Italy.
Daniele BellaviaIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Ortopedico Rizzoli, Scienze e Tecnologie Chirurgiche, 40136 Bologna, Italy.ORCID 0000-0003-3308-9112
Marialaura BonaccioResearch Unit of Epidemiology and Prevention, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) NEUROMED, 86077 Isernia, Italy.
Annalisa Di NucciDepartment of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, 00161 Rome, Italy.
Chiara DonfrancescoDepartment of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-8040-5571
Simona EspositoDepartment of Medicine and Surgery, Libera Università Mediterranea (LUM) University, 70010 Bari, Italy.
Paolo GandulliaUnità Operativa Centrale (UOC) Gastroenterologia ed Endoscopia Digestiva, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) G. Gaslini, 1647 Genoa, Italy.ORCID 0000-0002-7901-4995
Gianluca GiavaresiIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Ortopedico Rizzoli, Scienze e Tecnologie Chirurgiche, 40136 Bologna, Italy.ORCID 0000-0001-7843-5969
Monica GiroliCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20138 Milan, Italy.ORCID 0000-0002-9200-8821
Brunella GrigoloLaboratorio RAMSES, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0002-3990-6745
Francesco GrassiLaboratorio RAMSES, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Francesco LeonardiFondazione Italiana per l'Educazione Alimentare (FEI), 20214 Milan, Italy.
Elisa ProiettiDepartment of Internal Medicine and Medical Specialties (DI.M.I.), University of Genoa, 16145 Genoa, Italy.ORCID 0009-0000-0204-5753
Laura SciaccaSection of Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, 16145 Catania, Italy.ORCID 0000-0002-3258-7200
Licia IacovielloResearch Unit of Epidemiology and Prevention, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) NEUROMED, 86077 Isernia, Italy.ORCID 0000-0003-0514-5885
Antonella AgodiDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.ORCID 0000-0002-4405-8162

Funding

Italian Ministry of Health FSC 2014-2020, Traiettoria 5 - Linea di azione 5.1, cod. T5-AN-11 "Functional Foods Italy Net-work"
6 · The paper itself

Abstract

BACKGROUND/

objectivesNutrition during the reproductive years shapes women's immediate health, fertility, pregnancy outcomes, and long-term offspring well-being. This position paper narratively synthesizes and critically appraises evidence on how dietary patterns, macro-/micronutrients, and supplementation influence women's health, female fertility, and reproductive outcomes, to inform practical recommendations.

methodsWe narratively reviewed recent reviews, cohort studies, clinical trials, and public-health guidance on macronutrients, key micronutrients, dietary patterns (with emphasis on the Mediterranean diet), ultra-processed food (UPF) intake, and targeted supplementation relevant to menstrual, metabolic, cardiovascular, skeletal, and reproductive outcomes.

resultsBalanced, diverse diets rich in whole and minimally processed foods support hormonal regulation, ovulatory function, healthy gestation, and chronic-disease risk reduction. Priority nutrients include iron, folate, calcium, vitamin D, zinc, vitamin B12, and long-chain omega-3s (DHA), with supplementation considered when dietary intake or bioavailability is inadequate. Evidence consistently links Mediterranean-style eating to improved metabolic health, insulin sensitivity, IVF success, lower gestational diabetes risk, and favorable neonatal outcomes. High UPF consumption is associated with poorer diet quality, inflammation, adverse pregnancy outcomes, and potential reproductive impairment, warranting a reduction in favor of nutrient-dense foods. Diet also influences cardiovascular and bone health through effects on lipids, glycemia, blood pressure, and mineral/vitamin status, with fiber-rich carbohydrates, unsaturated fats (notably olive oil), and adequate calcium-vitamin D emerging as central levers.

conclusionsFor women of childbearing age, a Mediterranean-aligned, minimally processed dietary pattern-tailored to individual needs and complemented by prudent use of folate, iron, vitamin D, calcium, B12, and DHA when indicated-offers robust benefits across reproductive, metabolic, cardiovascular, and skeletal domains. Public-health actions should improve access to healthy foods, curb UPF marketing, and embed personalized nutrition counseling in routine care; further longitudinal research from preconception through postpartum is needed.

Indexed as

DietMaternal Nutritional Physiological PhenomenaWomen's HealthAdultDietary SupplementsDiet, MediterraneanFemaleFertilityHumansMicronutrientsNutritional StatusPregnancyPregnancy OutcomeMicronutrientschildbearing agedietnutritionnutritional recommendations

Identifiers

PMID41305556
PMCPMC12655777

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.