Evidence map›Paper›PMID 41305516›Full record

ArticleViruses2025

Different HLA Alleles Frequencies and Their Association with Clinical Phenotypes of Acute Respiratory Infections in Children.

Natalia V Palyanova, Olesia V Ohlopkova, Alexey D Moshkin, Kristina A Stolbunova, Marina A Stepanyuk, Ivan A Sobolev, Olga G Kurskaya, Alexander M Shestopalov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natalia V PalyanovaFederal State Budgetary Scientific Institution "Federal Research Center for Fundamental and Translational Medicine", 630117 Novosibirsk, Russia.ORCID 0000-0002-1783-5798
Olesia V OhlopkovaFederal State Budgetary Scientific Institution "Federal Research Center for Fundamental and Translational Medicine", 630117 Novosibirsk, Russia.ORCID 0000-0002-8214-7828
Alexey D MoshkinFederal State Budgetary Scientific Institution "Federal Research Center for Fundamental and Translational Medicine", 630117 Novosibirsk, Russia.ORCID 0000-0002-1182-8247
Kristina A StolbunovaFederal State Budgetary Scientific Institution "Federal Research Center for Fundamental and Translational Medicine", 630117 Novosibirsk, Russia.
Marina A StepanyukFederal State Budgetary Scientific Institution "Federal Research Center for Fundamental and Translational Medicine", 630117 Novosibirsk, Russia.
Ivan A SobolevFederal State Budgetary Scientific Institution "Federal Research Center for Fundamental and Translational Medicine", 630117 Novosibirsk, Russia.
Olga G KurskayaFederal State Budgetary Scientific Institution "Federal Research Center for Fundamental and Translational Medicine", 630117 Novosibirsk, Russia.
Alexander M ShestopalovFederal State Budgetary Scientific Institution "Federal Research Center for Fundamental and Translational Medicine", 630117 Novosibirsk, Russia.

Funding

Ministry of Science and Higher Education of Russia for the Research Institute of Virology of the Federal Research Center for Physics and Technology FGMU-2025-0009Russian Science Foundation 23-64-00005
6 · The paper itself

Abstract

The histocompatibility gene complex plays a vital role in the body's immune response to infections. In this work, we analyzed clinical data for 195 children hospitalized with signs of ARI in Siberia and performed genetic analysis for them. Genotyping was performed by high-throughput sequencing (NGS) using the HLA-Expert kit on the MiSeq Illumina platform. The frequencies of HLA allelic variants were calculated for each variant. For the variants detected in 20 patients or more, odds ratios (OR) were calculated for two pairs of conditions: severe/non-severe course of ARI and hypoxia/no hypoxia on admission. Six allelic variants were identified for which the odds ratio showed a significant (

Indexed as

Gene FrequencyHLA AntigensRespiratory Tract InfectionsAdolescentAllelesChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGenotypeHigh-Throughput Nucleotide SequencingHumansInfantMalePhenotypeSiberiaHLA AntigensARIchildrenHLAinfluenzaNGS sequencingSARS-CoV-2

Identifiers

PMID41305516
PMCPMC12656961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.