Evidence map›Paper›PMID 41305465›Full record

ArticleViruses2025

Diagnostic Performance of a Silver-Amplified vs. a Non-Amplified Lateral Flow Kit for Adenoviral Conjunctivitis: A Multicenter Prospective Study.

Tsuguto Fujimoto, Nozomu Hanaoka, Kenichiro Takahashi, Hisatoshi Kaneko, Masaaki Kobayashi, Hisashi Nakagawa, Hiroshi Hatano, Tomoko Tsukahara-Kawamura, Hironori Migita, Kentaro Nakamura and 2 more

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tsuguto FujimotoDepartment of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo 162-8640, Japan.ORCID 0000-0002-4861-4349
Nozomu HanaokaCenter for Emergency Preparedness and Response, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.ORCID 0000-0002-1039-6278
Kenichiro TakahashiCenter for Emergency Preparedness and Response, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.ORCID 0000-0001-8306-9553
Hisatoshi KanekoHobara Eye Clinic, Date 960-0612, Japan.
Masaaki KobayashiKobayashi Pediatric Clinic, Fujieda 426-0067, Japan.
Hisashi NakagawaTokushima Eye Clinic, Tokyo 189-0024, Japan.
Hiroshi HatanoHatano Eye Clinic, Fujisawa 251-0052, Japan.
Tomoko Tsukahara-KawamuraDepartment of Ophthalmology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.
Hironori MigitaMigita Eye Clinic, Chikushino 818-0083, Japan.ORCID 0000-0002-6984-7678
Kentaro NakamuraFUJIFILM Corporation, Tokyo 107-0052, Japan.
Kiyoharu KuramotoFUJIFILM Corporation, Tokyo 107-0052, Japan.
Eiichi UchioDepartment of Ophthalmology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.ORCID 0000-0002-9586-4164

Funding

Ministry of Health, Labour and Welfare Grant-in-Aid for Scientific Research 16809509
6 · The paper itself

Abstract

Accurate diagnosis of adenoviral conjunctivitis is critical for timely treatment and infection control. However, conventional lateral flow kits often lack sufficient sensitivity, especially in mild cases. This multicenter prospective study evaluated the diagnostic performance of silver-amplified lateral flow kits (SA-LFKs) compared with non-silver-amplified kits (NSA-LFKs), using real-time polymerase chain reaction (qPCR) as the reference standard. Tear samples from 200 patients with suspected adenoviral conjunctivitis were collected across four clinics and analyzed for sensitivity, specificity, and genotype coverage. The SA-LFK demonstrated significantly higher sensitivity (86.0%) than the NSA-LFK (72.0%) (

Indexed as

Adenoviruses, HumanAdenovirus Infections, HumanConjunctivitis, ViralReagent Kits, DiagnosticSilverAdultChildChild, PreschoolFemaleGenotypeHumansMaleMiddle AgedProspective StudiesReal-Time Polymerase Chain ReactionSensitivity and SpecificityReagent Kits, DiagnosticSilveradenoviral conjunctivitisdiagnostic accuracyepidemic keratoconjunctivitislateral flow assay

Identifiers

PMID41305465
PMCPMC12656814

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.