Evidence map›Paper›PMID 41305439›Full record

ArticleViruses2025

IL-2 and IL-7 Contribution to Immune Response: Effects of Vaccination Against COVID-19 in Adults.

Dominika Siedlecka, Lena Bielawska, Aleksandra Ludziejewska, Aleksandra Baszczuk, Ewa Wysocka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dominika SiedleckaDepartment of Laboratory Diagnostics, Poznan University of Medical Sciences, 60-569 Poznan, Poland.ORCID 0000-0003-1550-2794
Lena BielawskaDepartment of Laboratory Diagnostics, Poznan University of Medical Sciences, 60-569 Poznan, Poland.ORCID 0000-0002-4791-9175
Aleksandra LudziejewskaDepartment of Laboratory Diagnostics, Poznan University of Medical Sciences, 60-569 Poznan, Poland.ORCID 0000-0003-4405-8266
Aleksandra BaszczukDepartment of Laboratory Diagnostics, Poznan University of Medical Sciences, 60-569 Poznan, Poland.ORCID 0000-0002-9215-0799
Ewa WysockaDepartment of Laboratory Diagnostics, Poznan University of Medical Sciences, 60-569 Poznan, Poland.ORCID 0000-0002-4101-7656

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytokines participate in regulating the immune response of lymphocytes. Interleukin 2 (IL-2) is the main modulator of T lymphocyte development, homeostasis, and function, whereas interleukin 7 (IL-7) regulates the development and homeostasis of immune cells and plays a crucial role in the maintenance of memory cells. The study aims to assess the blood IL-2 and IL-7 concentration in relation to the obtained cellular and humoral response in adults, six months after vaccination against COVID-19.

methodsWe measured the concentration of IL-2 and IL-7 with ELISA, CoV2-IgG with an indirect chemiluminescence test, and the levels of IFN-γ with interferon gamma release assay (IGRA) post SARS-CoV-2 antigen stimulation. The study group (

resultsChrD-Pos group presented higher IL-7 compared to ChrD-Neg (

conclusionsThe interaction of IL-2 and IL-7 may be important for achieving post-vaccination immunity, especially in adults with chronic diseases. Age is a factor modifying the post-vaccination response (decreased IL-2), whereas IL-7 may be an important factor in achieving a satisfactory post-vaccine response in people with chronic diseases.

Indexed as

COVID-19COVID-19 VaccinesInterleukin-2Interleukin-7SARS-CoV-2AdultAgedAntibodies, ViralFemaleHumansImmunity, CellularImmunity, HumoralImmunoglobulin GInterferon-gammaMaleMiddle AgedAntibodies, ViralCOVID-19 VaccinesIL2 protein, humanIL7 protein, humanImmunoglobulin GInterferon-gammaInterleukin-2Interleukin-7COVID-19immunityinterleukin-2interleukin-7SARS-CoV-2vaccine

Identifiers

PMID41305439
PMCPMC12656904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.